{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:24:10Z","timestamp":1761578650899,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to evaluate the very long\u2010term clinical outcome after radioactive stent (RS) implantation and intracoronary \u03b2 radiation brachytherapy (IRBT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Radioactive stents (RS) and intracoronary \u03b2 radiation brachytherapy (IRBT) were introduced to prevent restenosis after percutaneous coronary intervention (PCI). Both techniques were associated with a higher incidence of major adverse cardiac events (MACE) in the short and intermediate\u2010term follow up as compared to conventional PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and thirty\u2010three patients received radioactive stents (<jats:sup>32<\/jats:sup>P) and 301 patients were treated with IRBT adjunctive to PCI. These groups were propensity matched to respectively 266 and 602 control patients who were treated with routine PCI during the same inclusion period. Endpoints were all\u2010cause mortality and MACE, defined as all\u2010cause death, any myocardial infarction or any revascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median follow\u2010up duration was 17\u2009years. All\u2010cause mortality rates were similar in all groups. Adjusted hazard ratios for MACE and mortality in the RS cohort were 1.55 (95% CI 1.20\u20132.00) and 0.92 (95% CI 0.63\u20131.34), respectively. Adjusted hazard ratios for MACE and all\u2010cause mortality in the IRBT cohort were 1.41 (95% CI 1.18\u20131.67) and 0.95 (95% CI 0.74\u20131.21), respectively. The difference in MACE rates was predominantly driven by coronary revascularizations in both groups, with a higher MI rate in the IRBT group as well.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Coronary radiation therapy was associated with early increased MACE rates, but the difference in MACE rates decreased beyond 2\u2009years, resulting in a comparable long\u2010term clinical outcome. Importantly, no excess in mortality was observed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28637","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T22:40:35Z","timestamp":1575326435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Two decades after coronary radiation therapy: A single center longitudinal clinical study"],"prefix":"10.1002","volume":"96","author":[{"given":"Sumant P.","family":"Radhoe","sequence":"first","affiliation":[{"name":"Department of Cardiology Thoraxcenter, Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Sophie","family":"Schuurman","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thoraxcenter, Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2544-5255","authenticated-orcid":false,"given":"Jurgen M.","family":"Ligthart","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thoraxcenter, Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Witberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thoraxcenter, Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter P. 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