{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T18:44:04Z","timestamp":1772736244535,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Incidence and outcomes of acute coronary syndrome (ACS) immediately following transcatheter aortic valve replacement (TAVR) remain largely unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study sought to assess the incidence, clinical characteristics, and outcomes of ACS following TAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We queried the National Readmission Database from January 2012 to September 2015 for TAVR admissions with and without ACS, creating a propensity\u2010matched cohort to compare outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 48,454 patients underwent TAVR, with 1,332 (2.75%) developing ACS. TAVR patients with ACS compared to those without ACS had a significantly higher incidence of acute kidney injury (24.7 vs. 19.2%; <jats:italic>p<\/jats:italic> =\u2009.001), ischemic stroke (3.7 vs. 2.3%; <jats:italic>p<\/jats:italic> =\u2009.04), vascular complications (8.6 vs. 5.8%; <jats:italic>p<\/jats:italic> =\u2009.008), cardiogenic shock (9.8 vs. 1.9%; <jats:italic>p<\/jats:italic> &lt;\u2009.001), cardiac arrest (5.1 vs. 2.8%; <jats:italic>p<\/jats:italic> =\u2009.002), mechanical circulatory support (8.1 vs. 1.5%; <jats:italic>p<\/jats:italic> &lt;\u2009.001), and in\u2010hospital mortality (9.6 vs. 3.4%; <jats:italic>p<\/jats:italic> &lt;\u2009.001). Additionally, TAVR with ACS had longer lengths of stay (median 10\u2009days vs. 6\u2009days; <jats:italic>p<\/jats:italic> &lt;\u2009.001) and hospital charges (median $23,200 vs. $19,000; <jats:italic>p<\/jats:italic> &lt;\u2009.001). Positive predictors of ACS were history of PCI (odds ratio, 1.43; 95% CI: 1.25\u20131.63), hyperlipidemia (odds ratio, 1.20; 95% CI: 1.07\u20131.34), chronic blood loss anemia (odds ratio, 2.16; 95% CI: 1.54\u20133.03), chronic kidney disease (odds ratio, 1.17; 95% CI: 1.04\u20131.31), fluid and electrolyte disorders (odds ratio, 1.65; 95% CI: 1.47\u20131.85), and weight loss (odds ratio, 1.53; 95% CI: 1.22\u20131.91). Heart failure (34%) was the most common reason for readmission in the ACS cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ACS after TAVR is uncommon but is associated with worse clinical outcomes and increased healthcare resource utilization.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28648","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T10:09:31Z","timestamp":1577095771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Incidence, outcomes, and predictors of in\u2010hospital acute coronary syndrome following endovascular transcatheter aortic valve replacement in the United States"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8202-9576","authenticated-orcid":false,"given":"Salik","family":"Nazir","sequence":"first","affiliation":[{"name":"Department of Cardiology University of Toledo Medical Center  Toledo Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keerat R.","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart and Vascular Institute, Cleveland Clinic  Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Donato","sequence":"additional","affiliation":[{"name":"Tower Health\/Reading Hospital  West Reading Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Grande","sequence":"additional","affiliation":[{"name":"Promedica Toledo Hospital  Toledo Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Changal","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Toledo Medical Center  Toledo Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0218-3317","authenticated-orcid":false,"given":"Mohamed M.","family":"Gad","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart and Vascular Institute, Cleveland Clinic  Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anas","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart and Vascular Institute, Cleveland Clinic  Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beni R.","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart and Vascular Institute, Cleveland Clinic  Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mubbasher A.","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Toledo Medical Center  Toledo Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mujeeb","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Toledo Medical Center  Toledo Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0026-3391","authenticated-orcid":false,"given":"Samir","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart and Vascular Institute, Cleveland Clinic  Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Kasi","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Promedica Toledo Hospital  Toledo Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400590"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514616"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1700456"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60308-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816885"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00563-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.03.034"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.05.071"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27251"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV7I5A90"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.03.089"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000029"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx391"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.182615"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.033"},{"key":"e_1_2_6_18_1","unstructured":"THE HCUP NATIONWIDE READMISSIONS DATABASE (NRD);2015.https:\/\/www.hcup-us.ahrq.gov\/db\/nation\/nrd\/Introduction_NRD_2010-2015.jsp. Accessed September 10 2019."},{"key":"e_1_2_6_19_1","unstructured":"HCUP\u2010US Methods Series;2019.https:\/\/www.hcup-us.ahrq.gov\/reports\/methods\/methods.jsp. Accessed September 10 2019."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199801000-00004"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.06.012"},{"key":"e_1_2_6_22_1","first-page":"688","article-title":"Hemodynamics in the Valsalva sinuses after transcatheter aortic valve implantation (TAVI)","volume":"22","author":"Ducci A","year":"2013","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509233"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.03.033"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.14740\/cr559w"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2014.06.004"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.6.708"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.09.001"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007230"},{"key":"e_1_2_6_30_1","doi-asserted-by":"crossref","first-page":"e002590","DOI":"10.1161\/JAHA.115.002590","article-title":"Ischemic stroke risk after acute coronary syndrome","volume":"5","author":"Yaghi S","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.09.030"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.01.219"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl182"},{"key":"e_1_2_6_34_1","first-page":"567","article-title":"Atherosclerosis and cirrhosis of the liver","volume":"53","author":"Van\u0115cek R","year":"1976","journal-title":"Bull World Health Organ"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2001.26063"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.1474"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.004472"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27838"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.111.000101"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.28648","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28648","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.28648","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T05:59:24Z","timestamp":1693807164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.28648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,23]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/ccd.28648"],"URL":"https:\/\/doi.org\/10.1002\/ccd.28648","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,23]]},"assertion":[{"value":"2019-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}