{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:18:34Z","timestamp":1780449514116,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the independent clinical impact of stent structural features in a large cohort of patients undergoing unprotected left main (ULM) or coronary bifurcation percutaneous coronary intervention (PCI) with a range of very thin strut stents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical impact of structural features of contemporary stents remains to be defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All consecutive patients enrolled in the veRy thin stents for patients with left mAIn or bifurcatioN in real life (RAIN) registry were included. The following stent structural features were studied: antiproliferative drugs (everolimus vs. sirolimus vs. zotarolimus), strut material (platinum\u2010chromium vs. cobalt\u2010chromium), polymer (bioresorbable vs. durable), number of crowns (&lt;8 vs. \u22658) and number of connectors (&lt;3 vs. \u22653). For small diameter stents (\u22642.5\u2009mm), struct thickness (74 vs. 80\/81\u2009\u03bcm) was also tested. Target lesion failure (TLF), a composite of target lesion revascularization and stent thrombosis, was the primary endpoint. Multivariate analysis was performed with Cox regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 2,707 patients, 110 (4.1%) experienced a TLF event after 16\u2009months (12\u201318). After adjustment for confounders, an increased number of connectors (adjusted hazard ratio [adj\u2010HR] 0.62, 95% confidence interval (CI) 0.39\u20130.99, p = .04) reduced risk of TLF, driven by stents with \u22652.5\u2009mm diameter (HR 0.54, 95% CI 0.32\u20130.93, p = .02). This independent relationship was lost for stents with diameter &lt;2.5\u2009mm, where only strut thickness appeared to impact. Conversely, no independent relationship of polymer type, number of crowns, and the specific limus\u2010family eluted drug with outcomes was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among a range of contemporary very thin stent models, an increased number of connectors improved device\u2010related outcomes in this investigated high\u2010risk procedural setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28667","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T13:33:57Z","timestamp":1576848837000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of structural features of very thin stents implanted in unprotected left main or coronary bifurcations on clinical outcomes"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0571-3918","authenticated-orcid":false,"given":"Mario","family":"Iannaccone","sequence":"first","affiliation":[{"name":"Division of Cardiology SS. Annunziata Hospital  Savigliano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-9317","authenticated-orcid":false,"given":"Fabrizio","family":"D'Ascenzo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Citt\u00e0 della Salute e della Scienza University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-6844","authenticated-orcid":false,"given":"Guglielmo","family":"Gallone","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Citt\u00e0 della Salute e della Scienza University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8972-4352","authenticated-orcid":false,"given":"Satoru","family":"Mitomo","sequence":"additional","affiliation":[{"name":"Unit of Cardiovascular Interventions, IRCCS San Raffaele Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7304-7315","authenticated-orcid":false,"given":"Rados\u0142aw","family":"Parma","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Structural Heart Diseases Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6319-4119","authenticated-orcid":false,"given":"Daniela","family":"Trabattoni","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences Centro Cardiologico Monzino, IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Ryan","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC, and Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Muscoli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease Tor Vergata University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3486-1039","authenticated-orcid":false,"given":"Giuseppe","family":"Venuti","sequence":"additional","affiliation":[{"name":"Division of Cardiology Ferrarotto Hospital, University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Montabone","sequence":"additional","affiliation":[{"name":"Department of Cardiology S.G. Bosco Hospital  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"De Lio","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Citt\u00e0 della Salute e della Scienza University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Zaccaro","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Citt\u00e0 della Salute e della Scienza University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4164-2758","authenticated-orcid":false,"given":"Giorgio","family":"Quadri","sequence":"additional","affiliation":[{"name":"Department of Cardiology Infermi Hospital  Rivoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4915-9501","authenticated-orcid":false,"given":"Ovidio","family":"De Filippo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Citt\u00e0 della Salute e della Scienza University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Wojakowski","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Structural Heart Diseases Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rognoni","sequence":"additional","affiliation":[{"name":"Coronary Care Unit and Catheterization Laboratory A.O.U. Maggiore della Carit\u00e0  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Helft","sequence":"additional","affiliation":[{"name":"Pierre and Marie Curie University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Gallo","sequence":"additional","affiliation":[{"name":"PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering Politecnico di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"De Luca","sequence":"additional","affiliation":[{"name":"Division of Cardiology S. Giovanni Evangelista Hospital  Tivoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Figini","sequence":"additional","affiliation":[{"name":"Pederzoli Hospital  Peschiera del Garda Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Imori","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Conrotto","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Citt\u00e0 della Salute e della Scienza University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Boccuzzi","sequence":"additional","affiliation":[{"name":"Department of Cardiology S.G. Bosco Hospital  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Mattesini","sequence":"additional","affiliation":[{"name":"Division of Structural Interventional Cardiology Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1220-9496","authenticated-orcid":false,"given":"Wojciech","family":"Wa\u0144ha","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Structural Heart Diseases Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Smolka","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Structural Heart Diseases Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenon","family":"Huczek","sequence":"additional","affiliation":[{"name":"Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Rolfo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Infermi Hospital  Rivoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Pennone","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Citt\u00e0 della Salute e della Scienza University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5808-7810","authenticated-orcid":false,"given":"Bernardo","family":"Cortese","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit ASST Fatebenefratelli\u2010Sacco  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Capodanno","sequence":"additional","affiliation":[{"name":"Division of Cardiology Ferrarotto Hospital, University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaide","family":"Chieffo","sequence":"additional","affiliation":[{"name":"Unit of Cardiovascular Interventions, IRCCS San Raffaele Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1779-3102","authenticated-orcid":false,"given":"Ivan","family":"Nu\u00f1ez\u2010Gil","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC,\u2009and Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Morbiducci","sequence":"additional","affiliation":[{"name":"PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering Politecnico di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"D'Amico","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Citt\u00e0 della Salute e della Scienza University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Varbella","sequence":"additional","affiliation":[{"name":"Department of Cardiology Infermi Hospital  Rivoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Romeo","sequence":"additional","affiliation":[{"name":"Department of Medicine Universit\u00e0 degli Studi di Roma \u2018Tor Vergata\u2019  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imad","family":"Sheiban","sequence":"additional","affiliation":[{"name":"Pederzoli Hospital  Peschiera del Garda Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Escaned","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos IDISSC,\u2009and Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Garbo","sequence":"additional","affiliation":[{"name":"Department of Cardiology S.G. Bosco Hospital  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Moretti","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Citt\u00e0 della Salute e della Scienza University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"di Mario","sequence":"additional","affiliation":[{"name":"Division of Structural Interventional Cardiology Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano M.","family":"De Ferrari","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Citt\u00e0 della Salute e della Scienza University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.01.011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.097014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31920-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.03.038"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.03.051"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.02.013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.003210"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034456"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32249-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28228"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.23.2816"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.061"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.4376"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.12.005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1210816"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH06-10-0586"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.110.957548"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.002943"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302519"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew070"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-726X(200005)50:1<120::AID-CCD26>3.0.CO;2-T"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.11.002"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.02.014"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2012.2196275"},{"key":"e_1_2_9_27_1","article-title":"Dual antiplatelet therapy strategies and clinical outcomes for a polymer\u2010free biolimus A9\u2010coated stent","author":"D'ascenzo F","year":"2019","journal-title":"EuroIntervention"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.052"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.03.005"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.02.136"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.28667","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28667","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.28667","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:12:58Z","timestamp":1693959178000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.28667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,20]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/ccd.28667"],"URL":"https:\/\/doi.org\/10.1002\/ccd.28667","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,20]]},"assertion":[{"value":"2019-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}