{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:14:35Z","timestamp":1758266075964,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The ULISSE registry evaluated the real\u2010world performance of the Ultimaster\u00ae biodegradable polymer sirolimus\u2010eluting stent (BP\u2010SES) in a multicenter\u2010independent cohort of patients undergoing percutaneous coronary intervention, including a large proportion of diabetes mellitus (DM) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this subgroup analysis, 1,660 consecutive patients, 2,422 lesions, treated with BP\u2010SES enrolled in the ULISSE registry were divided in two groups: DM (485 patients, 728 lesions) and non\u2010DM (1,175 patients, 1,694 lesions). Primary endpoint was target lesion failure (TLF), a composite endpoint of cardiac\u2010death, target\u2010vessel myocardial infarction (TV\u2010MI), and clinically driven target lesion revascularization (TLR) at 1\u2010year. Secondary endpoint was TLR at 1\u2010year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 1\u2010year follow\u2010up TLF occurred in 5% overall patients and was significantly higher in DM patients (8 vs. 3.7%; <jats:italic>p<\/jats:italic> = .001), due to more cardiac deaths (3.4 vs. 1.1%; <jats:italic>p<\/jats:italic> = .002). TLR occurred in 3.2% overall patients, and it was not significantly higher in DM compared to non\u2010DM patients (4.4 vs. 2.8%; <jats:italic>p<\/jats:italic> = .114). The incidence of stent thrombosis was low and similar between groups (0.4 vs. 0.9%; <jats:italic>p<\/jats:italic> = .526). Insulin\u2010treated DM (ITDM) patients showed higher rate of TLF as compared to non\u2010ITDM patients (13 vs. 6.5%; <jats:italic>p<\/jats:italic> = .041), but similar rate of TLR (6 vs. 4%; <jats:italic>p<\/jats:italic> = .405). After adjustment for relevant comorbidities, DM was not significantly associated with TLF or cardiac death in patients undergoing BP\u2010SES implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study is the first all\u2010comers evaluation of BP\u2010SES in DM patients. Our findings show that DM patients, mostly those with ITDM, still represent a vulnerable population and experience significantly higher rate of TLF. Overall BP\u2010SES efficacy is considerable, although not statistically significant higher rate of TLR is still present in DM compared to non\u2010DM patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28694","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T14:04:59Z","timestamp":1578319499000},"page":"255-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["One\u2010year clinical outcome of biodegradable polymer sirolimus\u2010eluting stent in diabetic patients: Insight from the ULISSE registry (ULtimaster Italian multicenter all comerS Stent rEgistry)"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2130-1964","authenticated-orcid":false,"given":"Alessandro","family":"Beneduce","sequence":"first","affiliation":[{"name":"Ospedale San Raffaele  Milan 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