{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:52:22Z","timestamp":1789750342219,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Contrast\u2010induced nephropathy (CIN) is associated with increased mortality and morbidity in patients undergoing coronary angiography (CAG) and percutaneous coronary intervention (PCI). We aimed to assess the latest evidence on the effect of remote ischemic preconditioning (RIPC) on the incidence of CIN in patients undergoing CAG\/PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a comprehensive search on topics assessing RIPC and CIN in CAG\/PCI patients from inception up until July 2019 through several electronic databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were a total of 1,925 subjects from 14 randomized controlled trials. Remote ischemic preconditioning was associated with reduced CIN incidence in patients undergoing CAG\/PCI (OR 0.41 [0.30, 0.55], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>: 22%). The nephroprotective effect was also demonstrated in those at moderate\u2010high risk for CIN subgroup (OR 0.41 [0.29, 0.58], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>: 26%) and PCI\u2010only subgroup (OR 0.41 [0.29, 0.58], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>: 0%). Time from RIPC to CAG\/PCI has similar effectiveness among \u226445, \u226460, and \u2264120\u2009min. Mortality, rehospitalization, hemodialysis, and major adverse events were lower in the RIPC group (OR 0.50 [0.33, 0.76], <jats:italic>p<\/jats:italic> = .001; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>: 0%). Grading of recommendations assessment, development and evaluation (GRADE) assessment showed that RIPC has high evidence certainty for reducing CIN in patients undergoing PCI\/CAG, moderate\u2010high risk subgroup, and PCI\u2010only subgroup with absolute reduction of 97 per 1,000, 129 per 1,000, and 121 per 1,000, respectively. Harbord test showed no evidence for the presence of small\u2010study effects (<jats:italic>p<\/jats:italic> = .157).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Remote ischemic preconditioning is an effective procedure to reduce the risk of CIN and should be considered in patients with moderate\u2010high risk at developing CIN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28709","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T10:59:27Z","timestamp":1578481167000},"page":"1200-1212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Remote ischemic preconditioning reduces the incidence of contrast\u2010induced nephropathy in patients undergoing coronary angiography\/intervention: Systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3998-6551","authenticated-orcid":false,"given":"Raymond","family":"Pranata","sequence":"first","affiliation":[{"name":"Faculty of Medicine Universitas Pelita Harapan  Tangerang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2317-5212","authenticated-orcid":false,"given":"Alexander E.","family":"Tondas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas Sriwijaya, Department of Cardiology and Vascular Medicine Mohammad Hoesin General Hospital  Palembang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4780-6592","authenticated-orcid":false,"given":"Rachel","family":"Vania","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas Pelita Harapan  Tangerang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9556-3994","authenticated-orcid":false,"given":"Mangiring P. 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