{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:52:45Z","timestamp":1782971565084,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The FUTURE\u2010I study aimed to assess preliminary safety and effectiveness with the long\u2010term clinical and imaging follow\u2010up for the Firesorb (MicroPort, Shanghai, China), a thinner\u2010strut sirolimus\u2010eluting bioresorbable scaffold (BRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>First\u2010generation BRS has been associated with unexpected device\u2010related adverse outcomes at long\u2010term follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective, open\u2010label, first\u2010in\u2010man study, patients with single de novo lesions in native coronary arteries were randomized 2:1 into two cohorts after successful Firesorb implantation: cohort 1 (<jats:italic>n<\/jats:italic> = 30) underwent multimodality imaging assessment at 6 and 24\u2009months; and cohort 2 (<jats:italic>n<\/jats:italic> = 15) at 12 and 36\u2009months. All patients underwent clinical follow\u2010up at 1, 6, and 12\u2009months and annually up to 5\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between January and March 2016, 45 patients were enrolled. At 3\u2010year follow\u2010up, one patient had experienced target lesion failure and none scaffold thrombosis. In\u2010scaffold minimal lumen diameter decreased significantly from 6\u2010month to 2\u2010year (2.53\u2009\u00b1\u20090.24\u2009mm vs. 2.27\u2009\u00b1\u20090.37\u2009mm, <jats:italic>p<\/jats:italic> = .0003), and only numerically from 1\u2010year to 3\u2010year follow\u2010up (2.48\u2009\u00b1\u20090.28\u2009mm vs. 2.22\u2009\u00b1\u20090.13\u2009mm, <jats:italic>p<\/jats:italic> = .08). By optical coherence tomography, neointimal strut coverage at 3\u2010year follow\u2010up was 99.8%, and very low rate of late scaffold discontinuity was observed, only in one patient on two cross sections with three malapposed struts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At 3\u2010year follow\u2010up of the FUTURE\u2010I study, implantation of the thinner\u2010strut Firesorb BRS appeared preliminary feasible and effective in the treatment of patients with noncomplex coronary lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28722","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T17:31:55Z","timestamp":1578418315000},"page":"648-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["First\u2010in\u2010man study of a thinner\u2010strut sirolimus\u2010eluting bioresorbable scaffold (FUTURE\u2010I): Three\u2010year clinical and imaging outcomes"],"prefix":"10.1002","volume":"95","author":[{"given":"Lei","family":"Song","sequence":"first","affiliation":[{"name":"Department of Cardiology Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwei","family":"Sun","sequence":"additional","affiliation":[{"name":"Catheterization Laboratories Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changdong","family":"Guan","sequence":"additional","affiliation":[{"name":"Catheterization Laboratories Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences  Beijing China"},{"name":"National Clinical Research Center for Cardiovascular Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyue","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingang","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaowei","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yida","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences  Beijing China"},{"name":"National Clinical Research Center for Cardiovascular Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Medical Research and Biometrics Center National Center for Cardiovascular Diseases  Beijing 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