{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:54:08Z","timestamp":1770918848004,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901825"],"award-info":[{"award-number":["81901825"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We evaluated the safety and usefulness of preparatory anatomical reshaping with a geometric hourglass\u2010shaped balloon to optimize transcatheter aortic valve replacement (TAVR) outcomes in bicuspid aortic valve (BAV) stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>TAVR has been increasingly performed for BAV stenosis; however, technical challenges remain. Procedural results are suboptimal given unfavorable valvular anatomies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible patients with BAV stenosis were enrolled to undergo aortic valve predilatation with the hourglass\u2010shaped TAV8 balloon before TAVR using the self\u2010expandable Venus A\u2010Valve. Procedural details and outcomes were compared to a sequential group of patients with BAV who underwent TAVR with the same device following preparatory dilatation using a cylindrical balloon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 22 patients were enrolled in the TAV8 group and 53 were included in the control group. Valve downsizing was less common in the TAV8 group (36.4 vs. 67.9%; <jats:italic>p<\/jats:italic> = .012). Stable valve release and optimal implant depth were consistently achieved in the TAV8 group with no requirement for a second valve (0 vs. 17.0%; <jats:italic>p<\/jats:italic> = .039) and with higher device success rates (100.0 vs 77.4%; <jats:italic>p<\/jats:italic> = .014). Residual aortic regurgitation graded as \u2265mild was less common in the TAV8 group (13.6 vs 45.3%; <jats:italic>p<\/jats:italic> = .009). Mortality was similar (0 vs. 3.8%; <jats:italic>p<\/jats:italic> = 1); no major\/disabling stroke or conversion to open\u2010heart surgery was seen in either group within 30\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with standard cylindrical balloon valvuloplasty, preparatory reshaping with the hourglass\u2010shaped balloon before self\u2010expandable TAVR in BAV was associated with significantly better procedural results and may encourage more promising outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28726","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T13:27:09Z","timestamp":1579008429000},"page":"616-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reshaping bicuspid aortic valve stenosis with an hourglass\u2010shaped balloon for transcatheter aortic valve replacement: A pilot study"],"prefix":"10.1002","volume":"95","author":[{"given":"Zhen\u2010Gang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Biao","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian\u2010Yuan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan\u2010Weixiang","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi\u2010Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Fu","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan\u2010Ning","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wesley R.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute Foundation Abbott Northwestern Hospital, Twin Cities Heart Foundation  Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin B.","family":"Leon","sequence":"additional","affiliation":[{"name":"Division of Cardiology Columbia University Medical Center and the Cardiovascular Research Foundation  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,14]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"KodaliSK WilliamsMR SmithCR et al;PARTNER Trial Investigators. Two\u2010year outcomes after transcatheter or surgical aortic\u2010valve replacement.N Engl J Med.2012;366:1686\u20101695."},{"key":"e_1_2_7_3_1","unstructured":"AdamsDH PopmaJJ ReardonMJ et al;U.S. CoreValve Clinical Investigators. Transcatheter aortic\u2010valve replacement with a self\u2010expanding prosthesis.N Engl J Med.2014;370:1790\u20101798."},{"key":"e_1_2_7_4_1","unstructured":"LeonMB SmithCR MackMJ et al;PARTNER 2 Investigators. Transcatheter or surgical aortic\u2010valve replacement in intermediate\u2010risk patients.N Engl J Med.2016;374:1609\u20101620."},{"key":"e_1_2_7_5_1","unstructured":"ReardonMJ Van MieghemNM PopmaJJ et al;SURTAVI Investigators. Surgical or transcatheter aortic\u2010valve replacement in intermediate\u2010risk patients.N Engl J Med.2017;376:1321\u20101331."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.03.014"},{"key":"e_1_2_7_7_1","unstructured":"MackMJ LeonMB ThouraniVH et al;PARTNER 3 Investigators. Transcatheter aortic\u2010valve replacement with a balloon\u2010expandable valve in low\u2010risk patients.N Engl J Med.2019;380:1695\u20101705."},{"key":"e_1_2_7_8_1","unstructured":"PopmaJJ DeebGM YakubovSJ et al;Evolut Low Risk Trial Investigators. Transcatheter aortic\u2010valve replacement with a self\u2010expanding valve in low\u2010risk patients.N Engl J Med.2019;380:1706\u20101715."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.01.390"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25863"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26912"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.039"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.04.066"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.06.041"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.03.017"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.023"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.161"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008313430903"},{"key":"e_1_2_7_19_1","first-page":"411","article-title":"Improvement in aortic valve area in patients with aortic stenosis through use of a new \"hourglass\u2010shaped\" valvuloplasty balloon","volume":"29","author":"Goldenberg E","year":"2017","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_7_20_1","unstructured":"SievertH.Venus A\u2010Valve: technology review and case examples. Presented at: TCT2014; September 15 2014; Washington DC."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.639450"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.001"},{"key":"e_1_2_7_23_1","first-page":"764","article-title":"Elliptical shape of a SAPIEN XT prosthesis deployed in a patient with bicuspid aortic valve stenosis","volume":"21","author":"Zegdi R","year":"2012","journal-title":"J Heart Valve Dis"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.28726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.28726","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T15:34:19Z","timestamp":1694014459000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.28726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,14]]},"references-count":22,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1002\/ccd.28726"],"URL":"https:\/\/doi.org\/10.1002\/ccd.28726","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,14]]},"assertion":[{"value":"2019-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}