{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:05:34Z","timestamp":1787508334206,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"This study was funded through a research grant from Shockwave Medical"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peripheral arterial disease (PAD) is one of the most common manifestations of atherosclerotic disease worldwide. Peripheral arterial calcification reduces acute success and long\u2010term patency of endovascular therapy for PAD. Several calcium modification devices are available for use in peripheral interventions. Outcomes after peripheral intravascular lithotripsy (IVL), a novel approach using pulsatile sonic waves to treat luminal and medial calcium in patients with PAD, have not been extensively characterized. Therefore, we sought to perform an individual patient\u2010level data (IPD) pooled analysis of available studies to evaluate the efficacy and safety of IVL in the treatment of PAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We pooled IPD, including baseline and procedural variables, from five prospective studies which assessed IVL in the treatment of patients with extensive peripheral artery calcification. Final postprocedural percent diameter stenosis (%DS) and procedural angiographic complications were assessed by independent core laboratory. Efficacy endpoints were analyzed using linear mixed effects models and safety endpoints were tabulated overall and by vascular bed. Among 336 patients who underwent endovascular revascularization with use of IVL, there was a significant reduction between pre\u2010procedural and final %DS of 55.1% (95% confidence interval 53.3\u201357.0%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u2009.0001). Core\u2010laboratory assessed lesion\u2010level complications, including flow\u2010limiting dissections (Types D\u2013F), vessel perforation, distal embolization, thrombus, abrupt closure, and no reflow, occurred in 4\/328 (1.22%) of treated lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present IPD of five prospective studies, marking the largest analysis to date evaluating the use of IVL in significantly calcified PAD lesions, demonstrates this treatment strategy to be both effective and safe.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.28729","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T05:48:58Z","timestamp":1579499338000},"page":"959-968","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Efficacy and safety of intravascular lithotripsy for the treatment of peripheral arterial disease: An individual patient\u2010level pooled data analysis"],"prefix":"10.1002","volume":"95","author":[{"given":"Mahesh V.","family":"Madhavan","sequence":"first","affiliation":[{"name":"Division of Cardiology and Center for Interventional Vascular Therapy NewYork\u2010Presbyterian Hospital\/Columbia University Irving Medical Center  New York New York"},{"name":"Clinical Trials Center Cardiovascular Research Foundation  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahira","family":"Shahim","sequence":"additional","affiliation":[{"name":"Clinical Trials Center Cardiovascular Research Foundation  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Mena\u2010Hurtado","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Diseases, Yale\u2010New Haven Hospital Yale University School of Medicine  New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Garcia","sequence":"additional","affiliation":[{"name":"Section of Interventional and Peripheral Vascular Interventions, Steward St. Elizabeth's Medical Center  Boston Massachusetts"},{"name":"Section of Interventional and Peripheral Vascular Interventions, Tufts University School of Medicine  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Crowley","sequence":"additional","affiliation":[{"name":"Clinical Trials Center Cardiovascular Research Foundation  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7740-1481","authenticated-orcid":false,"given":"Sahil A.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Center for Interventional Vascular Therapy NewYork\u2010Presbyterian Hospital\/Columbia University Irving Medical Center  New York New York"},{"name":"Clinical Trials Center Cardiovascular Research Foundation  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.03.483"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25387"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.306717"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.06.022"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27943"},{"key":"e_1_2_8_8_1","unstructured":"HoldenA. Disrupt PAD III Abstract. Paper presented at: Charing Cross; 2019; London England."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1526602818783989"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1526602819844998"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.12.2114"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-01056"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25046"},{"key":"e_1_2_8_14_1","first-page":"355","article-title":"The COMPLIANCE 360 degrees trial: a randomized, prospective, multicenter, pilot study comparing acute and long\u2010term results of orbital atherectomy to balloon angioplasty for calcified femoropopliteal disease","volume":"26","author":"Dattilo R","year":"2014","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2011.05.013"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1583\/JEVT-12-3815MR.1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000471"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.09.024"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31824c39ba"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.1.64"},{"key":"e_1_2_8_21_1","first-page":"I70","article-title":"Femoropopliteal angioplasty. Factors influencing long\u2010term success","volume":"83","author":"Capek P","year":"1991","journal-title":"Circulation"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1526602819827295"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004519"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.12.036"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.28729","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28729","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.28729","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T11:52:12Z","timestamp":1694087532000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.28729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,20]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/ccd.28729"],"URL":"https:\/\/doi.org\/10.1002\/ccd.28729","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,20]]},"assertion":[{"value":"2019-12-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}