{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:27:26Z","timestamp":1762918046565},"reference-count":29,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Lepu Medical, Beijing, China"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to evaluate the safety and efficacy of Nano+\u2122 (Lepu Medical, Beijing, China) stent implantation in all\u2010comer patients at the 1\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The Nano+\u2122 stent is a novel polymer\u2010free sirolimus\u2010eluting stent polymer that employs nanoporous stent surface technology to control drug\u2010delivery. The Nano+\u2122 stent is one of the most widely used drug\u2010eluting stent (DES) in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 2,481 consecutive patients were included in the multicenter and prospective NANO registry. In this study, the primary endpoint was target lesion failure (TLF) at 1\u2010year follow\u2010up, defined as a composite of cardiac death, target vessel nonfatal myocardial infarction (TV\u2010MI), and clinically driven target lesion revascularization (TLR). The safety endpoint was the occurrence of definite or probable stent thrombosis (ST).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Up to 40.2% of patients presented with acute myocardial infarction (AMI). A total of 63.9% of the 2,904 lesions were American College of Cardiology\/American Heart Association (ACC\/AHA) type B2 or C lesions. One\u2010year follow\u2010up data were available for 98.4% of patients. The 1\u2010year rate of TLF was 3.1% with rates of 1.3, 1.8, and 0.4% for clinically driven TLR, cardiac death, and TV\u2010MI, respectively. ST occurred in 0.4% of patients. Diabetes mellitus, AMI, left ventricular ejection fraction &lt;40% and long lesions (&gt;40\u2009mm) were independent predictors of 1\u2010year TLF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The 1\u2010year clinical outcomes were excellent for Nano+\u2122 polymer\u2010free SES implantation in an all\u2010comer patient population. Follow\u2010up will be extended up to 5\u2009years, to further elucidate the potential long\u2010term clinical benefits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p>URL:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/\">https:\/\/www.clinicaltrials.gov\/<\/jats:ext-link>. Unique identifier: NCT02929030.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28734","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T11:17:57Z","timestamp":1579605477000},"page":"658-664","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["One\u2010year clinical results of the NANO registry: A multicenter, prospective all\u2010comers registry study in patients receiving implantation of a polymer\u2010free sirolimus\u2010eluting stent"],"prefix":"10.1002","volume":"95","author":[{"given":"Yi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of The Fourth Military Medical University Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaojun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xuzhou Third People's Hospital Xuzhou 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