{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:30:14Z","timestamp":1793075414873,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim was to assess long\u2010term outcome after deferring intervention of coronary lesions with a fractional flow reserve (FFR) value of &gt;0.80 in a real\u2010world patient population and then to identify factors associated with deferred target lesion failure (DTLF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Deferring coronary interventions of intermediate lesions based on FFR measurement is safe, irrespective of the extent of coronary artery disease. However, FFR values near the cut\u2010off of &gt;0.80 may have less favorable outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was performed in patients with deferred coronary intervention based on FFR value &gt;0.80. The primary endpoint was DTLF, a composite of acute coronary syndrome (ACS) and any coronary revascularization, related to the initially deferred stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 600 patients, mean age of 66\u2009\u00b1\u200910\u2009years, and 751 coronary lesions with negative FFR values (mean 0.88\u2009\u00b1\u20090.04) were included. The mean follow\u2010up was 27\u2009\u00b1\u200915\u2009months. DTLF occurred in 44 patients (7.3%), revascularization in 42 (7%), and ACS without revascularization in 2 patients (0.3%). Patients with DTLF more often had diabetes mellitus, previous coronary artery bypass grafting, multivessel disease (MVD), and lower FFR at inclusion. Multivariable regression analysis showed that lower deferred FFR values [FFR 0.81\u20130.85: hazard ratio (HR) 2.79 (95% CI [confidence interval]; 1.46\u20135.32), <jats:italic>p<\/jats:italic> .002], MVD [HR 1.98 (95% CI; 1.05\u20133.75), <jats:italic>p<\/jats:italic> .036], distal lesions [HR 2.43 (95% CI; 1.29\u20134.57), <jats:italic>p<\/jats:italic> .006], and lesions located in a saphenous vein graft (SVG) [HR 6.35 (95% CI; 1.81\u201322.28), <jats:italic>p<\/jats:italic> .004] were independent predictors for DTLF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The long\u2010term rate of DTLF of initially deferred coronary lesions was 7.3%. Independent predictors for DTLF are lower deferred FFR value, the presence of MVD, distal lesions, and lesions in SVG.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28753","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T13:05:51Z","timestamp":1580389551000},"page":"247-256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Long\u2010term outcome after deferred revascularization due to negative fractional flow reserve in intermediate coronary lesions"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9369-3453","authenticated-orcid":false,"given":"Jerremy","family":"Weerts","sequence":"first","affiliation":[{"name":"Department of Cardiology Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM), Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4301-4843","authenticated-orcid":false,"given":"Tobias","family":"Pustjens","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Department of Cardiology Zuyderland Medical Centre  Heerlen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Ilhan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Department of Cardiology Zuyderland Medical Centre  Heerlen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo F.","family":"Veenstra","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Department of Cardiology Zuyderland Medical Centre  Heerlen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph A. L. J.","family":"Theunissen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jindrich","family":"Vainer","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mera","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zuyderland Medical Centre  Heerlen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lex A. 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