{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:40:49Z","timestamp":1747147249967,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A large trial established the favorable profile of a new polymer\u2010free biolimus A9\u2010eluting stent (PF\u2010BES) with a 1\u2010month dual antiplatelet therapy (DAPT) in high bleeding risk (HBR) patients. This is the first study comparing outcomes for a 1\u2010month versus longer DAPT strategies following PF\u2010BES\u2010percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients undergoing PF\u2010BES\u2010PCI (January 2016 to July 2018) were included in the multicenter CHANCE registry. Patients were stratified according to DAPT strategy at discharge (planned 1\u2010month vs. planned &gt;1\u2010month). Primary outcomes were the 390\u2010day estimates of a patient\u2010oriented and of a device\u2010oriented composite endpoints (POCE: death, myocardial infarction [MI] or target vessel revascularization; DOCE: cardiac death, target vessel\u2010MI or ischemia\u2010driven target lesion revascularization). Landmark analyses from 1\u2010month post\u2010PCI were carried.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following PF\u2010BES\u2010PCI, 328(40.3%) and 485(59.6%) patients were discharged with 1\u2010month and longer DAPT (12\u2009months [6\u201312]), respectively. Patients with a previous or index MI were less likely to be discharged on 1\u2010month DAPT. Patients prescribed with 1\u2010month DAPT were more likely to be at HBR than those with longer DAPT (90.2% vs. 69.9%, <jats:italic>p<\/jats:italic> = .001). No between\u2010groups differences in the primary outcomes (planned 1\u2010month vs. planned &gt;1\u2010month DAPT: POCE 11.9% vs. 13.2%, <jats:italic>p<\/jats:italic> = .747; DOCE: 4.8% vs. 8.1%, <jats:italic>p<\/jats:italic> = .500) were observed, also after adjusting for confoundings (POCE: adjusted\u2010hazard ratio [adj\u2010HR] 1.26, 95%CI 0.74\u20132.13; DOCE: adj\u2010HR 1.00, 95%CI 0.49\u20131.99). Landmark analyses showed similar results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a large all\u2010comers registry of PF\u2010BES PCI, no interaction of planned DAPT strategy (1\u2010month vs. &gt;1\u2010month) with outcomes was found. This observation warrants investigation in adequately powered randomized studies (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> NCT03622203).<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28757","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T19:07:59Z","timestamp":1580756879000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010world reasons and outcomes for 1\u2010month versus longer dual antiplatelet therapy strategies with a polymer\u2010free BIOLIMUS A9\u2010coated stent"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-6844","authenticated-orcid":false,"given":"Guglielmo","family":"Gallone","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Citt\u00e0 della Salute e della Scienza  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-9317","authenticated-orcid":false,"given":"Fabrizio","family":"D'Ascenzo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Citt\u00e0 della Salute e della Scienza  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Boccuzzi","sequence":"additional","affiliation":[{"name":"Division of Cardiology San Giovanni Bosco  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5808-7810","authenticated-orcid":false,"given":"Bernardo","family":"Cortese","sequence":"additional","affiliation":[{"name":"U.O.C. Cardiologia Ospedale Fatebenefratelli, ASST Fatebenefratelli\/Sacco  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Di Biasi","sequence":"additional","affiliation":[{"name":"U.O.C. Cardiologia Ospedale Sacco, ASST Fatebenefratelli\/Sacco  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluigi","family":"Omed\u00e8","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Citt\u00e0 della Salute e della Scienza  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Capodanno","sequence":"additional","affiliation":[{"name":"Division of Cardiology Ferrarotto Hospital, University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Cerrato","sequence":"additional","affiliation":[{"name":"Department of Cardiology Infermi Hospital  Rivoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Vicinelli","sequence":"additional","affiliation":[{"name":"U.O.C. Cardiologia Ospedale di Magenta, ASST Milanese Ovest  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3825-3487","authenticated-orcid":false,"given":"Vincenzo","family":"Infantino","sequence":"additional","affiliation":[{"name":"Division of Cardiology Ospedale Civile  Ciri\u00e8 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaldo","family":"Poli","sequence":"additional","affiliation":[{"name":"U.O.C. 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