{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:12:36Z","timestamp":1789517556405,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to assess the outcomes of cardiogenic shock (CS) complicating acute coronary syndromes (ACS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>CS remains the leading cause of mortality in patients presenting with ACS despite advances in care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 13,184 patients undergoing percutaneous coronary intervention (PCI) for all subtypes of ACS enrolled prospectively in a large multicentre Australian registry (Melbourne Interventional Group registry) from 2005 to 2013. All\u2010cause mortality was obtained via linkage to the National Death Index. Patients were divided into those with and those without CS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the non\u2010CS group (<jats:italic>n<\/jats:italic> =\u200912,548, 95.2%), the CS group (<jats:italic>n<\/jats:italic> =\u2009636, 4.8%) had a higher proportion of out\u2010of\u2010hospital cardiac arrest (OHCA) (31.1 vs. 2.2%) and ST\u2010elevation myocardial infarction (STEMI) presentation (89 vs. 34%), both <jats:italic>p<\/jats:italic> &lt;\u2009.01. Patients in the CS group had higher rates of in\u2010hospital (40.4 vs. 1.2%) and 30\u2010day (41 vs. 1.7%) mortality compared to the non\u2010CS group. Long\u2010term mortality over a median follow\u2010up of 4.2\u2009years was higher in the CS group (50.6 vs. 13.8%), <jats:italic>p<\/jats:italic> &lt;\u2009.001. Trends of in\u2010hospital and 30\u2010day mortality rates of CS complicating ACS were relatively stable from 2005 to 2013. Predictors of long\u2010term NDI\u2010linked mortality within the CS group include severe left ventricular systolic dysfunction (HR 3.0), glomerular filtration rate (GFR) &lt;30 (HR 2.56), GFR 30\u201359 (HR 1.94), OHCA (HR 1.46), diabetes (HR 1.44), and age (HR 1.02), all <jats:italic>p<\/jats:italic> &lt;\u2009.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Rates of CS\u2010related mortality complicating ACS have remained very high and steady over nearly a decade despite progress in STEMI systems of care, PCI techniques, and medical therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28759","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T07:40:29Z","timestamp":1580802029000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Outcomes of cardiogenic shock complicating acute coronary syndromes"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8760-5373","authenticated-orcid":false,"given":"Samer","family":"Noaman","sequence":"first","affiliation":[{"name":"Department of Cardiology Alfred Health  Melbourne Victoria Australia"},{"name":"Department of Medicine University of Melbourne  Melbourne Victoria Australia"},{"name":"Clinical Research Domain, Baker IDI Heart and Diabetes Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Andrianopoulos","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, Centre of Cardiovascular Research and Education in Therapeutics (CCRE) Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela L.","family":"Brennan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, Centre of 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