{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T21:23:44Z","timestamp":1769117024184,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Left atrial (LA) volumes and function are believed to improve following interventional reduction of mitral regurgitation (MR) with MitraClip. However, exact LA alterations after MitraClip in patients with functional MR and functional mitral regurgitation (FMR) are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to evaluate the effect of MitraClip on LA volumes and global function in patients with FMR and its importance for patients' prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients underwent three\u2010dimensionally transthoracic echocardiography with an offline evaluation of LA geometry and strain analysis at baseline and follow\u2010up (FU). FU examinations were planned for 6 and 12 months after MitraClip.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We prospectively included 50 consecutive surgical high\u2010risk (logistic EuroSCORE: 17.2\u2009\u00b1\u200913.9%) patients (77\u2009\u00b1\u20099\u2009years, 22% female) with symptomatic moderate\u2010to\u2010severe to severe functional MR without atrial fibrillation.<\/jats:p><jats:p>Echocardiographic evaluation showed that the E\/E' ratio was significantly higher at FU (15.6\u2009\u00b1\u20097.3, 24.1\u2009\u00b1\u200913.2, <jats:italic>p<\/jats:italic> = .05) without relevant changes in systolic left ventricle (LV) function (<jats:italic>p<\/jats:italic> = .5). LA volumes (end\u2010diastolic volume [LA\u2010EDV] and end\u2010systolic volume [LA\u2010ESV]) (LA\u2010EDV: 83.1\u2009\u00b1\u200939.5 ml, 115.1\u2009\u00b1\u200955.3 ml, <jats:italic>p<\/jats:italic> = .012; LA\u2010ESV: 58.4\u2009\u00b1\u200933.4 ml, 80.1\u2009\u00b1\u200943.9 ml, <jats:italic>p<\/jats:italic> = .031), muscular mass (105.1\u2009\u00b1\u200949.3 g, 145.4\u2009\u00b1\u200970.6 g, <jats:italic>p<\/jats:italic> = .013), as well as LA stroke volume (24.6\u2009\u00b1\u200912.5 ml, 34.9\u2009\u00b1\u200919.1 ml, <jats:italic>p<\/jats:italic> = .016) significantly increased after the procedure. LA ejection fraction (LA\u2010EF: 31.7\u2009\u00b1\u200912.8%, 31.1\u2009\u00b1\u200912.3%, <jats:italic>p<\/jats:italic> = .8) and atrial global strain (aGS: \u221210.8\u2009\u00b1\u20095.4%, \u22129.7\u2009\u00b1\u20094.45%, <jats:italic>p<\/jats:italic> = .4) showed no significant changes at FU.<\/jats:p><jats:p>Despite no relevant changes during FU, the baseline aGS was found to be the strongest predictor for mortality and adverse interventional outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MitraClip increases atrial stroke volume, atrial volumes, and muscular mass in patients with FMR. We found that the baseline aGS the strongest predictor for mortality, rehospitalization, and higher residual MR at FU.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28775","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T14:17:55Z","timestamp":1581949075000},"page":"678-684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Left atrial global function in chronic heart failure patients with functional mitral regurgitation after MitraClip"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5419-2488","authenticated-orcid":false,"given":"Can","family":"\u00d6zt\u00fcrk","sequence":"first","affiliation":[{"name":"Heart Center Bonn, Department of Cardiology University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamana","family":"Fasell","sequence":"additional","affiliation":[{"name":"Heart Center Bonn, Department of Cardiology University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan\u2010Malte","family":"Sinning","sequence":"additional","affiliation":[{"name":"Heart Center Bonn, Department of Cardiology University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikos","family":"Werner","sequence":"additional","affiliation":[{"name":"Heart Center Bonn, Department of Cardiology University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Nickenig","sequence":"additional","affiliation":[{"name":"Heart Center Bonn, Department of Cardiology University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Hammerstingl","sequence":"additional","affiliation":[{"name":"Center for Heart Vascular Medicine Mediapark K\u00f6ln  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Schueler","sequence":"additional","affiliation":[{"name":"Contilia Heart and Vascular Center Elisabeth Hospital  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009355"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16862"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.01.054"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.07.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000087"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.1166"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.006036"},{"key":"e_1_2_8_9_1","first-page":"309","article-title":"Left atrial and left ventricular function and remodeling following percutaneous mitral valve repair","volume":"25","author":"Rammos C","year":"2016","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2018.03.011"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13288"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-7-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.21037\/cdt.2017.06.08"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2017.08.003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs079"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr029"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.07.079"},{"key":"e_1_2_8_18_1","first-page":"652","article-title":"Left ventricular remodelling patterns after MitraClip implantation in patients with severe mitral valve regurgitation: mechanistic insights and prognostic implications","volume":"5","author":"Brouwer HJ","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.006553"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1366216"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.02.003"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(03)00335-3"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.004229"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-011-9930-2"},{"key":"e_1_2_8_25_1","first-page":"23","article-title":"Time varying loading of the pulmonary circulation: a model to describe hemodynamic observations in the stiff left atrial syndrome","volume":"11","author":"Fitchett DH","year":"1995","journal-title":"Can J Cardiol"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.35.1.39"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.06.031"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806640"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.10.049"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011727"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.28775","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28775","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.28775","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:30:14Z","timestamp":1693960214000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.28775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,17]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/ccd.28775"],"URL":"https:\/\/doi.org\/10.1002\/ccd.28775","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,17]]},"assertion":[{"value":"2019-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}