{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T03:31:15Z","timestamp":1782012675958,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the predictors and clinical impact of left ventricular reverse remodeling (LVRR) after MitraClip (MC) therapy for degenerative (DMR) and functional mitral regurgitation (FMR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>MC therapy induces LVRR in patients with mitral regurgitation (MR) at high\u2010risk for surgery. However, specific data on predictors of LVRR therapy are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 164 patients treated by MC implantation with complete clinical and echocardiographic evaluation at baseline, 6\u2009months, and 12\u2009months. LVRR was defined as a decrease of \u226510% of the left ventricular end\u2010diastolic diameter after 12\u2009months and was found in 49% of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LVRR was associated with significantly reduced event rate 2\u2009years after MC procedure. In the total cohort, multivariate regression analysis determined severe recurrent\/residual MR after 12\u2009months (<jats:italic>p<\/jats:italic> =\u2009.010, odds ratio [OR] =\u20090.26), male gender (<jats:italic>p<\/jats:italic> =\u2009.050, OR = 0.49) and left ventricular ejection fraction (LVEF) &lt;20% (<jats:italic>p<\/jats:italic> =\u2009.046, OR = 0.24) as predictors of absence of LVRR. In the subgroup analysis according to etiology of MR, multivariate regression analysis revealed severe recurrent\/residual MR after 12\u2009months (<jats:italic>p<\/jats:italic> =\u2009.04, OR = 0.184) to inversely predict LVRR only in the DMR subgroup. In FMR, residual severe tricuspid regurgitation (TR) inversely predicts LVRR (<jats:italic>p<\/jats:italic> =\u2009.032, OR = 0.361).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LVRR occurs in half of the patients after MC and is associated with reduced MACCE rates at follow\u2010up. Combined information on residual\/recurrent MR, baseline LVEF and gender predict LVRR after MC procedure. While residual\/recurrent MR is the independent predictor for the absence of LVRR in DMR, in FMR only severe residual TR independently predict LVRR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28779","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T12:27:02Z","timestamp":1582806422000},"page":"687-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Predictors of left ventricular reverse remodeling after percutaneous therapy for mitral regurgitation with the MitraClip system"],"prefix":"10.1002","volume":"96","author":[{"given":"Nicoleta","family":"Nita","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II University of Ulm  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Scharnbeck","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II University of Ulm  Ulm 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