{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T20:48:49Z","timestamp":1769201329867,"version":"3.49.0"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Valve\u2010in\u2010valve (VIV) treatment with transcatheter aortic valve replacement (TAVR) is a viable option for patients with failing aortic bioprosthetic valves. Optimal management of those with concomitant mitral regurgitation (MR) remains undetermined. Therefore, we sought to assess the implications of concomitant MR in patients undergoing VIV\u2010TAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>The PARTNER 2 VIV registry enrolled patients with degenerated surgical aortic bioprosthesis at high risk for reoperation. Patients with core\u2010laboratory echocardiographic assessment of MR were analyzed; severe MR was excluded. We compared patients with \u2264mild MR versus moderate MR and assessed changes in MR severity and clinical outcomes.<\/jats:p><jats:p>A total of 339 patients (89 initial registry, 250 continued access) underwent VIV procedures; mean age 79.0\u2009\u00b1\u200910.2\u2009years, mean Society of Thoracic Surgeon score 8.9\u2009\u00b1\u20094.5%. At baseline, 228\/339 (67.3%) had \u2264mild MR and 111\/339 (32.7%) had moderate MR. In paired analysis, there was significant improvement in \u2265moderate MR from baseline to 30\u2009days (32.6% vs. 14.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001 [<jats:italic>n<\/jats:italic> = 304]), and no significant change between 30\u2009days and 1 year (13.4% vs. 12.1%, <jats:italic>p<\/jats:italic> = .56 [<jats:italic>n<\/jats:italic> = 224]) or 1 year and 2\u2009years (11.0% vs. 10.4%, <jats:italic>p<\/jats:italic> = .81 [<jats:italic>n<\/jats:italic> = 182]). There was no difference in death or stroke between \u2264mild MR and moderate MR at 30\u2009days (4.0% vs. 7.2%, <jats:italic>p<\/jats:italic> = .20), 1 year (15.5% vs. 15.3%, <jats:italic>p<\/jats:italic> = .98) or 2\u2009years (26.5% vs. 23.5%, <jats:italic>p<\/jats:italic> = .67).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Moderate concomitant MR tends to improve with VIV\u2010TAVR, and was not a predictor of long\u2010term adverse outcomes in this cohort. In selected patients undergoing VIV\u2010TAVR, it may be appropriate to conservatively manage concomitant MR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> NCT# 03225001.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28811","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T11:19:02Z","timestamp":1583147942000},"page":"981-986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mitral regurgitation in patients undergoing transcatheter aortic valve implantation for degenerated surgical aortic bioprosthesis: Insights from PARTNER 2 Valve\u2010in\u2010Valve Registry"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0488-8866","authenticated-orcid":false,"given":"Dale J.","family":"Murdoch","sequence":"first","affiliation":[{"name":"St Paul's Hospital University of British Columbia  Vancouver British Columbia Canada"},{"name":"School of Medicine University of Queensland  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9513-9440","authenticated-orcid":false,"given":"Janarthanan","family":"Sathananthan","sequence":"additional","affiliation":[{"name":"St Paul's Hospital University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9270-6446","authenticated-orcid":false,"given":"Mark","family":"Hensey","sequence":"additional","affiliation":[{"name":"St Paul's Hospital University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.","family":"Alu","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangbo","family":"Liu","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Crowley","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Wood","sequence":"additional","affiliation":[{"name":"St Paul's Hospital University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anson","family":"Cheung","sequence":"additional","affiliation":[{"name":"St Paul's Hospital University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1939-7573","authenticated-orcid":false,"given":"Jian","family":"Ye","sequence":"additional","affiliation":[{"name":"St Paul's Hospital University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1066-4962","authenticated-orcid":false,"given":"Ted","family":"Feldman","sequence":"additional","affiliation":[{"name":"NorthShore University Health System  Evanston Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1342-9191","authenticated-orcid":false,"given":"Rebecca T","family":"Hahn","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael A.","family":"Jaber","sequence":"additional","affiliation":[{"name":"Cleveland Clinic  Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Mack","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Health  Plano Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S Chris","family":"Malaisrie","sequence":"additional","affiliation":[{"name":"Northwestern University  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin B.","family":"Leon","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center  New York New York"},{"name":"Cardiovascular Research Foundation  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Webb","sequence":"additional","affiliation":[{"name":"St Paul's Hospital University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.02.057"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.03.018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.7246"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.04.074"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.01.022"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.05.025"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.09.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003885"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/24748706.2018.1475781"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.28811","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28811","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.28811","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.28811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T19:01:17Z","timestamp":1693854077000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.28811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,2]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/ccd.28811"],"URL":"https:\/\/doi.org\/10.1002\/ccd.28811","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,2]]},"assertion":[{"value":"2020-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}