{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:41:03Z","timestamp":1747147263560,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61975240","81670283"],"award-info":[{"award-number":["61975240","81670283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Via subclavian\/jugular vein, successful puncture of interventricular septum (IVS) has been achieved transvenously. However, the approach was limited by acute entry\u2010angle. The study was conducted to investigate a novel transcatheter puncture of IVS via femoral access and transfemoral\u2010venous access to left ventricle (LV) through IVS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Via femoral artery, transcatheter puncture of mid\u2010IVS was performed with a custom\u2010made nickel\u2013titanium needle and 6F\u2010sheath in 16 healthy mini\u2010swine. Then femoral arterio\u2010venous circuit was established through IVS. After pre\u2010dilation of IVS, a 20F\u2010sheath was introduced into LV transvenously over\u2010the\u2010guidewire in 15 swine. Furthermore, transfemoral\u2010venous TAVR was attempted with the approach in another swine. IVS was evaluated postoperatively and was further confirmed pathologically 2 months later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All transcatheter puncture of IVS was performed successfully in LV and the mid\u2010IVS thickness was 7.67\u2009\u00b1\u20090.98\u2009mm. In all swine, femoral arterio\u2010venous circuit was established via IVS, and a 20F\u2010sheath was introduced into LV and aorta transfemoral\u2010venously (entry\u2010angle: 145.3\u2009\u00b1\u200912.2\u00b0 in front view). After the procedure, there was one swine with moderate tricuspid\u2010regurgitation and five swine with mild residual\u2010shunt (2.6\u2009\u00b1\u20090.7\u2009mm). Two months later, residual\u2010shunt was still detected in three swine and the communication was confirmed pathologically. In other swine, no defect occurred and replacement\u2010scar was identified along puncture\u2010tract. In the swine underwent transfemoral\u2010venous TAVR, prosthetic valve was deployed successfully with good function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Transfemoral transcatheter puncture of IVS is feasible and safe in a swine model, and large sheath can be introduced into LV transfemoral\u2010venously using the novel access with the aid of vessel circuit.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28848","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T11:26:38Z","timestamp":1584444398000},"page":"488-496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transfemoral transcatheter puncture of interventricular septum in a swine model: A novel transfemoral\u2010venous access to left ventricle with the assistance of arterio\u2010venous circuit"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8864-5505","authenticated-orcid":false,"given":"Chaowu","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Structural Heart Disease Cardiovascular Institute and Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linyuan","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Structural Heart Disease Cardiovascular Institute and Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Cardiovascular Institute and Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing TongRen Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baopeng","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering China University of Petroleum  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shijie","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering China University of Petroleum  Beijing 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