{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:38:33Z","timestamp":1753886313309,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T00:00:00Z","timestamp":1584748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"OrbusNeich Medical; OrbusNeich Medical BV"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The COMBO drug eluting stent is a novel device with luminal endothelial progenitor cell capture technology for rapid homogeneous endothelialization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We examined for sex differences in 1\u2010year outcomes after COMBO stenting from the COMBO collaboration, a pooled patient\u2010level dataset from the MASCOT and REMEDEE multicenter registries. The primary endpoint was 1\u2010year target lesion failure (TLF), composite of cardiac death, target vessel\u2010myocardial infarction (TV\u2010MI), or clinically driven target lesion revascularization (CD\u2010TLR). Secondary outcomes included stent thrombosis (ST). Adjusted outcomes were assessed using Cox regression methods. The study included 861 (23.8%) women and 2,753 (76.2%) men. Women were older with higher prevalence of several comorbidities including diabetes mellitus. Risk of 1\u2010year TLF was similar in both sexes (3.8% vs. 3.9%, HR 0.92, 95% CI 0.59\u20131.42, <jats:italic>p<\/jats:italic> =\u2009.70), without sex differences in the incidence of cardiac death (1.6% vs. 1.5%, <jats:italic>p<\/jats:italic> =\u2009.78), TV\u2010MI (1.5% vs. 1.1%, <jats:italic>p<\/jats:italic> =\u2009.32), or CD\u2010TLR (2.0% vs. 2.2%, <jats:italic>p<\/jats:italic> =\u2009.67). Definite or probable ST occurred in 0.4% women and 1.0% men (HR 0.26, 95% CI 0.06\u20131.11, <jats:italic>p<\/jats:italic> =\u2009.069).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite greater clinical risks at baseline, women treated with COMBO stents had similarly low 1\u2010year TLF and other ischemic outcomes compared to men.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28853","type":"journal-article","created":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T07:09:39Z","timestamp":1584774579000},"page":"797-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sex differences in 1\u2010year clinical outcomes after percutaneous coronary intervention with COMBO stents: From the COMBO collaboration"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8776-326X","authenticated-orcid":false,"given":"Jaya","family":"Chandrasekhar","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai Hospital  New York USA"},{"name":"Amsterdam UMC, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0873-2014","authenticated-orcid":false,"given":"Laura S.","family":"Kerkmeijer","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah N.","family":"Kalkman","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Sartori","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai Hospital  New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa B.","family":"Aquino","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai Hospital  New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier","family":"Woudstra","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel A.","family":"Beijk","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan G.","family":"Tijssen","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel T.","family":"Koch","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"H\u00e1jek","sequence":"additional","affiliation":[{"name":"Motol University Hospital  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borislav","family":"Atzev","sequence":"additional","affiliation":[{"name":"University Hospital St. Ekaterina  Sofia Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Hudec","sequence":"additional","affiliation":[{"name":"SUSCCH, a.s. 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