{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:35:47Z","timestamp":1762868147890,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Polymer\u2010based bioresorbable scaffolds (PBBS) have been assessed for coronary revascularization with mixed outcomes. Few studies have targeted pediatric\u2010specific scaffolds. We sought to assess safety, efficacy, and short\u2010term performance of a dedicated drug\u2010free PBBS pediatric scaffold compared to a standard low\u2010profile bare metal stent (BMS) in central and peripheral arteries of weaned piglets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010two devices (22 Elixir poly\u2010L\u2010lactic\u2010acid\u2010based pediatric bioresorbable scaffolds [BRS] [6\u2009\u00d7\u200918\u2009mm] and 20 control BMS Cook Formula 418 [6\u2009\u00d7\u200920\u2009mm]) were implanted in the descending aorta and pulmonary arteries (PAs) of 14 female Yucatan piglets. Quantitative measurements were collected on the day of device deployment and 30 and 90\u2009days postimplantation to compare device patency and integrity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The BRS has a comparable safety profile to the BMS in the acute setting. Late lumen loss (LLL) and percent diameter stenosis (%DS) were not significantly different between BRS and BMS in the PA at 30\u2009days. LLL and %DS were greater for BRS versus BMS in the aorta at 30\u2009days postimplantation (LLL difference: 0.96\u2009\u00b1\u20090.26; %DS difference: 16.15\u2009\u00b1\u20094.51; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). At 90\u2009days, %DS in the aortic BRS was less, and PA BRS LLL was also less than BMS. Histomorphometric data showed greater intimal proliferation and area stenosis in the BRS at all time points and in all vessels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A dedicated PBBS pediatric BRS has a favorable safety profile in the acute\/subacute setting and demonstrates characteristics that are consistent with adult BRSs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28893","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T20:58:50Z","timestamp":1586984330000},"page":"878-888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>Preclinical<\/scp> comparative assessment of a dedicated pediatric poly\u2010L\u2010lactic\u2010acid\u2010based bioresorbable scaffold with a low\u2010profile bare metal stent"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2644-5425","authenticated-orcid":false,"given":"Kamel","family":"Shibbani","sequence":"first","affiliation":[{"name":"University of Iowa Hospitals and Clinics  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza","family":"De Lima e Silva Bagno","sequence":"additional","affiliation":[{"name":"University of Miami  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5217-6348","authenticated-orcid":false,"given":"Marie\u2010France","family":"Poulin","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Matella","sequence":"additional","affiliation":[{"name":"Rush University Medical Center  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Diab","sequence":"additional","affiliation":[{"name":"Rush University Medical Center  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifford","family":"Kavinsky","sequence":"additional","affiliation":[{"name":"Rush University Medical Center  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagarajan","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Elixir Medical Corporation  Milpitas California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinayak","family":"Bhat","sequence":"additional","affiliation":[{"name":"Elixir Medical Corporation  Milpitas California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyad M.","family":"Hijazi","sequence":"additional","affiliation":[{"name":"Sidra Medicine  Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4279-6102","authenticated-orcid":false,"given":"Damien","family":"Kenny","sequence":"additional","affiliation":[{"name":"Children's Hospital Ireland at Crumlin  Dublin 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