{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:41:10Z","timestamp":1747147270605,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970325"],"award-info":[{"award-number":["81970325"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We hypothesize that different degree of pre\u2010existing aortic regurgitation (AR) may affect the presence of hypo\u2010attenuated leaflet thickening (HALT) after transcatheter aortic valve replacement (TAVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The mechanism of the presence of HALT post\u2010TAVR is not fully understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated the post\u2010procedural multi\u2010slice computed tomography (MSCT) before discharge for evidence of HALT. Patients were grouped according to the degree of pre\u2010existing AR. Baseline, native anatomy and procedure details were compared, then multivariate regression was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MSCT analyzed was performed at a median of 6\u2009days post\u2010TAVR in 179 patients. HALT was detected in 10.6% of patients. After adjusting for variables that were significantly different between groups, pre\u2010existing\u2009\u2265\u2009moderate AR was protective to the risk of HALT (OR 0.15, 95% CI 0.03\u20130.84, <jats:italic>p<\/jats:italic> = .03). Stratifying for factors that might explain the impact of pre\u2010existing AR on HALT, patients with a small Sinus of Valsalva, non\u2010eccentric remodeling and receiving a large bioprosthesis experienced a sevenfold higher risk for HALT (OR 7.16, 95% CI 2.05\u201325.08, <jats:italic>p<\/jats:italic> = .002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients underwent TAVR with pre\u2010existing\u2009\u2265\u2009moderate AR appeared to experience a lower incidence of early HALT compared to those patients with less than moderate AR, which may be explained by a larger Sinus of Valsalva and a higher proportion of LV eccentric remodeling.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28903","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T07:33:30Z","timestamp":1589355210000},"page":"1491-1497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of concomitant aortic regurgitation on early hypo\u2010attenuated leaflet thickening after transcatheter aortic valve replacement in patients with symptomatic severe aortic stenosis"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8054-3512","authenticated-orcid":false,"given":"Tian\u2010Yuan","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Biao","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3755-5961","authenticated-orcid":false,"given":"Yi\u2010Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu PR 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