{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T19:10:51Z","timestamp":1781032251027,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["NIH 1R01HL139785\u201001"],"award-info":[{"award-number":["NIH 1R01HL139785\u201001"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The authors sought to evaluate 10\u2010year national trends, incidence and clinical outcomes of stroke in CS\u2010STEMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Stroke is a devastating complication among patients with ST\u2010elevation myocardial infarction (STEMI). Concomitant cardiogenic shock (CS) may further increase the risk of stroke. Use of percutaneous mechanical circulatory support (pMCS) devices may further increase stroke risk in CS\u2010STEMI. No studies have evaluated the risk of stroke in contemporary CS\u2010STEMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective cohort study of CS\u2010STEMI patients from a large U.S. national database between 2005 and 2014. Previously validated codes for stroke were used to identify events of ischemic or hemorrhagic stroke. They were then divided into different groups: without MCS, with intra\u2010aortic balloon pump, percutaneous ventricular assist device (PVAD, includes Impella or TandemHeart devices), or extracorporeal membrane oxygenation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 172,491 admissions, stroke was noted in 5,613 (3.2%). Between 2005 and 2014, we observed an increase in the events of overall stroke from 3.1% in 2005 to 5.0% in 2014 (<jats:italic>p<\/jats:italic> for the trend &lt;.001). The number of ischemic stroke events (2.4%) was higher than hemorrhagic stroke (0.1%) during the study period. Presence of stroke was associated with higher in\u2010hospital mortality (40.6 vs. 29.8%, 95% CI adjusted odds ratio: 1.57, 1.44\u20131.67; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001 among stroke vs. without stroke).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of stroke events in CS\u2010STEMI patients increased between 2005 and 2014, and is associated with higher in\u2010hospital mortality, length of stay, and cost of hospitalization. The incidence of both hemorrhagic and ischemic stroke was higher with pMCS device use. Stroke prevention is a priority for CS\u2010STEMI patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28919","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T19:26:10Z","timestamp":1588274770000},"page":"217-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Incidence and clinical outcomes of stroke in <scp>ST<\/scp>\u2010elevation myocardial infarction and cardiogenic shock"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7276-710X","authenticated-orcid":false,"given":"Mohit","family":"Pahuja","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Detroit Medical Center\/Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Chehab","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Detroit Medical Center\/Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar","family":"Ranka","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Kansas University Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Detroit Medical Center\/Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6827-8234","authenticated-orcid":false,"given":"Tomo","family":"Ando","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Columbia University Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed S.","family":"Yassin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Detroit Medical Center\/Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Thayer","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Tuft University Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palak","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiology Inova Heart and Vascular Institute  Fairfax Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1902-1739","authenticated-orcid":false,"given":"Carey D.","family":"Kimmelstiel","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department 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