{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:41:14Z","timestamp":1747147274680,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study investigated the effect of a drug\u2010coated stent (DCS) that has a novel microporous abluminal surface without a polymer on 1\u2010month and 1\u2010year functional and morphological healing response as assessed using acetylcholine (Ach) testing and optical coherence tomography (OCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>DCS is expected to induce favorable morphological and physiological arterial healing after its implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 11 patients who underwent vascular response examinations 1\u2010month and 1\u2010year after the index PCI with DCS implantation were enrolled. The vascular response was evaluated by the functional response test by acetylcholine infusion, the morphological response test by OCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although 94.5% of the DCS struts were covered by homogeneous smooth neointima at 1\u2009month, the percentage of neointimal coverage increased to 98.5% at 1\u2009year (<jats:italic>p<\/jats:italic> = .02). Conversely, the proportion of uncovered struts and malapposed struts at 1\u2009year were 1.2 and 0.7%, respectively. Furthermore, the coronary vasomotor response to incremental doses of Ach were impaired especially in the distal segments at each period, although the responses to Ach at 10<jats:sup>\u22126<\/jats:sup>\u2009mol\/L in the distal segment tended to improve over time from baseline to 1\u2009month and 1\u2009year later (\u221219\u2009\u00b1\u200920%, \u22129\u2009\u00b1\u200917%, and \u22125\u2009\u00b1\u200914%, respectively; <jats:italic>p<\/jats:italic> = .27).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The morphological assessment of DCS with OCT revealed a high degree of strut coverage and apposition at 4\u2009weeks after implantation. The impaired endothelium\u2010dependent vasomotor response tended to improve chronologically from baseline to 1\u2009month and 1\u2009year later.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.28938","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T22:04:05Z","timestamp":1588975445000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Short\u2010 and mid\u2010term influence of drug\u2010coated stent implantation on structural and functional vascular healing response: An optical coherence tomography and acetylcholine testing study"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1509-6071","authenticated-orcid":false,"given":"Hiroto","family":"Tamaru","sequence":"first","affiliation":[{"name":"Department of Cardiology Higashi Takarazuka Satoh Hospital  Takarazuka 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