{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T07:47:37Z","timestamp":1763279257227,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CeloNova"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Cobra PzF coronary stent is cobalt chromium with flat thin struts, nano\u2010coated with Polyzene\u2010F that enhance rapid reendothelialization and reduce the risk of stent thrombosis and restenosis. It is designed to overcome shortfalls of BMS and DES in patients requiring short DAPT duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To report procedural and 1\u2010year clinical outcomes following Cobra PzF stent implantation in routine practice PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>e\u2010Cobra registry is a multicenter prospective study to evaluate Cobra PzF stent in routine practice in patients deemed appropriate for short DAPT after PCI. The primary endpoint was MACE rate at 12\u2009months (Cardiac death, MI, TLR). The secondary endpoint was definite stent thrombosis at 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 940 patients (72% men, 72.8\u2009\u00b1\u200913.4\u2009years) with multiple co\u2010morbidities, 47% had acute coronary syndromes, and 62% were defined as high bleeding risk. A total of 1,229 lesions were treated with 1,314 stents. 36% of patients had lesion type B2 or C classification. Angiographic success was achieved in all cases. One\u2010year follow\u2010up was available for 97% of patients. The primary endpoint occurred in 9.0% of patients, including cardiac death 3.7%, MI 4.8%, and TLR 4.3%. Definite stent thrombosis occurred in six out of 915 (0.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Cobra PzF stent was safe and effective in routine practice patients and seems feasible in situations when short DAPT or Mono Antiplatelet Therapy (MAPT) is needed. One\u2010year follow\u2010up was associated with satisfactory clinical outcomes and validate previously reported data.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29065","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T07:40:10Z","timestamp":1592379610000},"page":"45-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of the safety and efficacy of the Cobra <scp>PzF NanoCoated<\/scp> coronary stent in routine, consecutive, prospective, and high\u2010risk patients: The <scp>e\u2010Cobra<\/scp> study"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6898-3045","authenticated-orcid":false,"given":"Luc","family":"Maillard","sequence":"first","affiliation":[{"name":"GCS ES Axium Rambot  Aix en Provence France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"de 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