{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:19:46Z","timestamp":1790734786713,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,6,28]],"date-time":"2020-06-28T00:00:00Z","timestamp":1593302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the additive prognostic value of myocardial, inflammatory, and renal biomarkers according to frailty status in patients undergoing transcatheter aortic valve replacement (TAVR) for aortic stenosis (AS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 111 subjects who underwent TAVR at Hospital Italiano de Buenos Aires, Argentina between January 2016 and December 2018 were retrospectively reviewed. Plasma levels of N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NT\u2010proBNP), high sensitivity troponin T (hs\u2010cTnT), C\u2010reactive protein (CRP), cystatin\u2010c (Cys\u2010C) and carbohydrate antigen\u2010125 (CA\u2010125) were assessed prior to TAVR. Frailty status was assessed according to the fried physical frailty phenotype (FPFP). The primary endpoint was defined as all\u2010cause death and\/or readmission for worsening congestive heart failure (CHF) within the first year after TAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 111 patients included, 48\/111 (43%) were considered to be \u201cfrail\u201d according to the FPFP. Among biomarkers, we found CA\u2010125 to be strongly associated with the primary endpoint (<jats:italic>p<\/jats:italic> = .006). CA\u2010125\u2009\u2265\u200918.2 U\/ml was present in 41% and was associated with a higher rate of the primary endpoint (31% vs. 9%; <jats:italic>p<\/jats:italic> = .003). After multivariable adjustment, CA\u2010125\u2009\u2265\u200918.2 U\/ml (hazard ratio [HR] 3.17; <jats:italic>p<\/jats:italic> = .024) was the only independent predictor of the primary endpoint. Finally, the inclusion of CA\u2010125 to frailty significantly improved C\u2010index (0.68\u20130.74; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), and provided a Net Reclassification Improvement (NRI) of 0.34 (95% CI 0.19\u20130.49, <jats:italic>p<\/jats:italic> = .031), largely through reductions in risk estimates among pre\u2010frail and frail patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CA\u2010125, a tumor biomarker, outperformed frailty for predicting the primary endpoint within the first year after TAVR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29067","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T05:16:22Z","timestamp":1593407782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Additive prognostic value of carbohydrate antigen\u2010125 over frailty in patients undergoing transcatheter aortic valve 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