{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:49:00Z","timestamp":1781531340916,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The IC-HOT study was sponsored by TherOx."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Supersaturated oxygen (SSO<jats:sub>2<\/jats:sub>) has recently been approved by the U.S. Food and Drug Administration for administration after primary percutaneous coronary intervention (pPCI) in patients with anterior ST\u2010segment elevation myocardial infarction (STEMI) based on its demonstration of infarct size reduction in the IC\u2010HOT study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the 1\u2010year clinical outcomes of intracoronary SSO<jats:sub>2<\/jats:sub> treatment after pPCI in patients with anterior STEMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>IC\u2010HOT was a prospective, open\u2010label, single\u2010arm study in which 100 patients without cardiogenic shock undergoing successful pPCI of an occluded left anterior descending coronary artery were treated with a 60\u2010min SSO<jats:sub>2<\/jats:sub> infusion. One\u2010year clinical outcomes were compared with a propensity\u2010matched control group of similar patients with anterior STEMI enrolled in the INFUSE\u2010AMI trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline and postprocedural characteristics were similar in the two groups except for pre\u2010PCI thrombolysis in myocardial infarction 3 flow, which was less prevalent in patients treated with SSO<jats:sub>2<\/jats:sub> (9.6% vs. 22.9%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02). Treatment with SSO<jats:sub>2<\/jats:sub> was associated with a lower 1\u2010year rate of the composite endpoint of all\u2010cause death or new\u2010onset heart failure (HF) or hospitalization for HF (0.0% vs. 12.3%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001). All\u2010cause mortality, driven by cardiovascular mortality, and new\u2010onset HF or HF hospitalization were each individually lower in SSO<jats:sub>2<\/jats:sub>\u2010treated patients. There were no significant differences between groups in the 1\u2010year rates of reinfarction or clinically driven target vessel revascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Infusion of SSO<jats:sub>2<\/jats:sub> following pPCI in patients with anterior STEMI was associated with improved 1\u2010year clinical outcomes including lower rates of death and new\u2010onset HF or HF hospitalizations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29090","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T14:40:42Z","timestamp":1594392042000},"page":"1120-1126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["One\u2010year outcomes of supersaturated oxygen therapy in acute anterior myocardial infarction: The IC\u2010HOT study"],"prefix":"10.1002","volume":"97","author":[{"given":"Shmuel","family":"Chen","sequence":"first","affiliation":[{"name":"Clinical Trials Center Cardiovascular Research Foundation  New York"},{"name":"Division of Cardiology NewYork\u2010Presbyterian Hospital\/Columbia University Irving Medical Center  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shukri W.","family":"David","sequence":"additional","affiliation":[{"name":"Providence Hospital  Southfield Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0451-9155","authenticated-orcid":false,"given":"Zubair A.","family":"Khan","sequence":"additional","affiliation":[{"name":"North Alabama Medical Center  Florence Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Christopher","family":"Metzger","sequence":"additional","affiliation":[{"name":"Ballad Health CVA Heart Institute  Kingsport Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hal S.","family":"Wasserman","sequence":"additional","affiliation":[{"name":"Danbury Hospital  Danbury Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir S.","family":"Lotfi","sequence":"additional","affiliation":[{"name":"Baystate Medical Center  Springfield Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0481-9764","authenticated-orcid":false,"given":"Ivan D.","family":"Hanson","sequence":"additional","affiliation":[{"name":"Beaumont Health System  Royal Oak Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon R.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Beaumont Health System  Royal Oak Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"LaLonde","sequence":"additional","affiliation":[{"name":"Ascension St. John Hospital  Detroit Michigan"},{"name":"Wayne State University School of Medicine  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5507-3712","authenticated-orcid":false,"given":"Philippe","family":"G\u00e9n\u00e9reux","sequence":"additional","affiliation":[{"name":"Clinical Trials Center Cardiovascular Research Foundation  New York"},{"name":"Gagnon Cardiovascular Institute, Morristown Medical Center  Morristown New Jersey"},{"name":"H\u00f4pital du Sacr\u00e9\u2010Coeur de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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