{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:49:46Z","timestamp":1773013786077,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Noninvasive fractional flow reserve (NiFFR) is an emerging method for evaluating the functional significance of a coronary lesion during diagnostic coronary angiography (CAG). The method relies on the computational flow dynamics and the three\u2010dimensional (3D) reconstruction of the vessel extracted from CAG. In the present study, we sought to evaluate the diagnostic performance and applicability of 2D\u2010based NiFFR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective observational study, we evaluated 2D\u2010based NiFFR in 279 candidates for invasive CAG and invasive fractional flow reserve (FFR). NiFFR was calculated via two methods: variable NiFFR, in which the contrast transport time was extracted from the angiographic view, and fixed NiFFR, in which a prespecified frame count was applied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final analysis was performed on 245 patients (250 lesions). Variable NiFFR had an area under the receiver operating characteristic curve of 81.5%, an accuracy of 80.0%, a sensitivity of 82.2%, a specificity of 82.2%, a negative predictive value of 91.4%, and a positive predictive value of 63.6%. The mean difference between FFR and NiFFR was \u22120.0244\u2009\u00b1.0616 (<jats:italic>p<\/jats:italic> \u2264.0001). A pressure wire\u2010free hybrid strategy was possible in 68.8% of our population with variable NiFFR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our 2D\u2010based NiFFR yielded results comparable to those derived from 3D\u2010based software. Our findings should; however, be confirmed in larger trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29150","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T10:16:12Z","timestamp":1595844972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic accuracy of two\u2010dimensional coronary angiographic\u2010derived fractional flow reserve\u2014Preliminary results"],"prefix":"10.1002","volume":"97","author":[{"given":"Hamid","family":"Babakhani","sequence":"first","affiliation":[{"name":"Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center Iran University of Medical Sciences  Tehran Iran"},{"name":"Energy Conversion Department, Faculty of Mechanical Engineering Tarbiat Modares University  Tehran 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