{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T21:11:44Z","timestamp":1769116304173,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to evaluate the feasibility of using three dimensional\u2010quantitative coronary angiography (3D\u2010QCA) based fractional flow reserve (FFR) (vessel fractional flow reserve [vFFR], CAAS8.1, Pie Medical Imaging) and to correlate vFFR values with intravascular ultrasound (IVUS) for the evaluation of intermediate left main coronary artery (LMCA) stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>3D\u2010QCA derived FFR indices have been recently developed for less invasive functional lesion assessment. However, LMCA lesions were vastly under\u2010represented in first validation studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This observational single\u2010center cohort study enrolled consecutive patients with stable angina, unstable angina, or non\u2010ST\u2010segment elevation myocardial infarction and nonostial, intermediate grade LMCA stenoses who underwent IVUS evaluation. vFFR was computed based on two angiograms with optimal LMCA stenosis projection and correlated with IVUS\u2010derived minimal lumen area (MLA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 256 patients with intermediate grade LMCA stenosis evaluated with IVUS were screened for eligibility; 147 patients met the clinical inclusion criteria and had a complete IVUS LMCA footage available, of them, 63 patients (63 lesions) underwent 3D\u2010QCA and vFFR analyses. The main reason for screening failure was insufficient quality of the angiogram (51 patients,60.7%). Mean age was 65\u2009\u00b1\u200911\u2009years, 75% were male. Overall, mean MLA within LMCA was 8.77\u2009\u00b1\u20093.17\u2009mm<jats:sup>2<\/jats:sup>, while mean vFFR was 0.87\u2009\u00b1\u20090.09. A correlation was observed between vFFR and LMCA MLA (<jats:italic>r\u2009=<\/jats:italic> .792, <jats:italic>p<\/jats:italic> = .001). The diagnostic accuracy of vFFR \u22640.8 in identifying lesions with MLA\u2009&lt;\u20096.0\u2009mm<jats:sup>2<\/jats:sup> (sensitivity 98%, specificity 71.4%, area under the curve (AUC) 0.95, 95% confidence interval (CI) 0.89\u20131.00, <jats:italic>p<\/jats:italic> = .001) was good.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with good quality angiographic visualization of LMCA and available complete LMCA IVUS footage, 3D\u2010QCA based vFFR assessment of LMCA disease correlates well to LMCA MLA as assessed by IVUS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29151","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T14:00:11Z","timestamp":1596031211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Correlation between 3D\u2010QCA based FFR and quantitative lumen assessment by IVUS for left main coronary artery stenoses"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-1393","authenticated-orcid":false,"given":"Mariusz","family":"Tomaniak","sequence":"first","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center, University Medical Center Rotterdam, Thorax Centre  Rotterdam The Netherlands"},{"name":"First Department of Cardiology Medical University of Warsaw  Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3100-7590","authenticated-orcid":false,"given":"Kaneshka","family":"Masdjedi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center, University Medical Center Rotterdam, Thorax Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8618-0318","authenticated-orcid":false,"given":"Laurens J","family":"van Zandvoort","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center, University Medical Center Rotterdam, Thorax Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Neleman","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center, University Medical Center Rotterdam, Thorax Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3207-3178","authenticated-orcid":false,"given":"Maria N","family":"Tovar Forero","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center, University Medical Center Rotterdam, Thorax Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alise","family":"Vermaire","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center, University Medical Center Rotterdam, Thorax Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Kochman","sequence":"additional","affiliation":[{"name":"First Department of Cardiology Medical University of Warsaw  Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Kardys","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center, University Medical Center Rotterdam, Thorax Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wijnand","family":"den Dekker","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center, University Medical Center Rotterdam, Thorax Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"Wilschut","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center, University Medical Center Rotterdam, Thorax Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2344-6705","authenticated-orcid":false,"given":"Roberto","family":"Diletti","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center, University Medical Center Rotterdam, Thorax Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"de Jaegere","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center, University Medical Center Rotterdam, Thorax Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas M","family":"Van Mieghem","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center, University Medical Center Rotterdam, Thorax Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Zijlstra","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center, University Medical Center Rotterdam, Thorax Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9081-5518","authenticated-orcid":false,"given":"Joost","family":"Daemen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center, University Medical Center Rotterdam, Thorax Centre  Rotterdam The 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