{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T16:45:28Z","timestamp":1768581928874,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T00:00:00Z","timestamp":1597449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter mitral valve repair (TMVR) is a treatment option for patients with 3+ or greater mitral regurgitation who cannot undergo mitral valve surgery. Outcomes in patients with chronic kidney disease (CKD) and end stage renal disease (ESRD) are unclear. We sought to evaluate the TMVR in\u2010hospital outcomes, readmission rates and its impact on kidney function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 2016 National Readmission Database was used to obtain all patients who underwent TMVR. Patients were classified by their CKD status: no CKD, CKD, or ESRD. The primary outcomes were: in\u2010hospital mortality, 30\u2010 and 90\u2010day readmission rate, and change in CKD status on readmission. Multivariable logistic regression analysis was used to assess in\u2010hospital, readmission outcomes and kidney function stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 4,645 patients were assessed (mean age 78.5 \u00b1\u200910.3\u2009years). In\u2010hospital mortality was higher in patients with CKD (4.0%, odds ratio [OR]:2.01 [95% CI, confidence interval: 1.27\u20133.18]) and ESRD (6.6%, OR: 6.38 [95% CI: 1.49\u201327.36]) compared with non\u2010CKD (2.4%). 30\u2010day readmission rate was higher in ESRD versus non\u2010CKD patients (17.8% vs. 10.4%, OR: 2.24 [95% CI: 1.30\u20133.87]) as was 90\u2010day readmission (41.2% vs. 21% OR: 2.51 [95% CI:1.70\u20133.72]). Kidney function improved in 25% of patients with CKD stage 3 and in 50% with CKD stage 4\u20135 at 30\u2010and 90\u2010day readmission. Incidence of AKI, major bleeding, and respiratory failure were higher in CKD group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with CKD and ESRD have worse outcomes and higher readmission rate after TMVR. In patients who were readmitted after TMVR, renal function improved in some patients, suggesting that TMVR could potentially improve CKD stage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29188","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T11:00:30Z","timestamp":1597489230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of chronic kidney disease on in\u2010hospital outcomes and readmission rate after edge\u2010to\u2010edge transcatheter mitral valve repair"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2643-0434","authenticated-orcid":false,"given":"Khalid","family":"Sawalha","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Massachusetts Medical School\u2010 Baystate Medical Center  Springfield Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Al\u2010Akchar","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Southern Illinois University School of Medicine  Springfield Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdisamad","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Southern Illinois University School of Medicine  Springfield Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Buhnerkempe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Clinical Research Southern Illinois University School of Medicine  Springfield Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron","family":"Koester","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Southern Illinois University School of Medicine  Springfield Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsin","family":"Salih","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Southern Illinois University School of Medicine  Springfield Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukul","family":"Bhattarai","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Southern Illinois University School of Medicine  Springfield Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitin","family":"Tandan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Southern Illinois University School of Medicine  Springfield Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1278-6245","authenticated-orcid":false,"given":"Deepak L.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Brigham and Women's Hospital Heart &amp; Vascular Center, Harvard Medical School  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Moiz","family":"Hafiz","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Southern Illinois University School of Medicine  Springfield Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009355"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806640"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.2976"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx402"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.03.011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.073"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx391"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2019.04.008"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000095676.90936.80"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1812279"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.496"},{"key":"e_1_2_9_13_1","unstructured":"Agency for Healthcare Research and Quality. 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