{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:59:50Z","timestamp":1772643590653,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to compare short\u2010term outcomes between transcatheter aortic valve replacement (TAVR) for pure aortic regurgitation (AR) and TAVR for aortic stenosis (AS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with severe pure AR for whom surgical valve replacement is infeasible, TAVR is sometimes used off\u2010label.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Nationwide Readmissions Database 2016\u20132017, we retrospectively identified patients without prior valve surgery who underwent endovascular TAVR. We compared in\u2010hospital and 30\u2010day outcomes according to the type of aortic valve disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 81,542 eligible patients were divided into the pure AR (<jats:italic>n<\/jats:italic> = 1,222, 1.50%), pure AS (<jats:italic>n<\/jats:italic> = 72,690, 89.1%), and AS + AR (<jats:italic>n<\/jats:italic> = 7,630, 9.36%) groups. In unadjusted analyses, the pure AR group, compared with the pure AS and AS + AR groups, showed a higher incidence of acute kidney injury (16.8% vs. 9.8% vs. 12.1%, respectively; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and need of surgical bailout (1.4% vs. 0.4% vs. 0.6%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). The pure AR group also showed higher in\u2010hospital mortality than the pure AS group (2.4% vs. 1.4%; <jats:italic>p<\/jats:italic> = .005). After multivariable adjustment, TAVR for pure AR was significantly associated with a higher risk of acute kidney injury (odds ratio [OR] = 1.64, 95% confidence interval [CI] = 1.33\u20132.02; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), cardiac tamponade (OR = 1.98, 95% CI = 1.00\u20133.92; <jats:italic>p<\/jats:italic> = .0498), and prolonged hospital stay (OR = 1.59, 95% CI = 1.29\u20131.95; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) compared with TAVR for pure AS, whereas it was not significantly associated with in\u2010hospital mortality (OR = 1.55, 95% CI = 0.99\u20132.45; <jats:italic>p<\/jats:italic> = .058) and other outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TAVR may be a reasonable treatment option for selected patients with pure AR with regard to short\u2010term outcomes. However, additional techniques or devices may be necessary to reduce periprocedural risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29189","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T00:22:49Z","timestamp":1598660569000},"page":"477-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Short\u2010term outcomes of transcatheter aortic valve replacement for pure native aortic regurgitation in the United States"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-6447","authenticated-orcid":false,"given":"Toshiaki","family":"Isogai","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0101-0131","authenticated-orcid":false,"given":"Anas M.","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keerat R.","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashank","family":"Shekhar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8025-9212","authenticated-orcid":false,"given":"Omar M.","family":"Abdelfattah","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0218-3317","authenticated-orcid":false,"given":"Mohamed M.","family":"Gad","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars G.","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Heart and Vascular Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6048-7955","authenticated-orcid":false,"given":"Amar","family":"Krishnaswamy","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0026-3391","authenticated-orcid":false,"given":"Samir R.","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.03.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx391"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816885"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00201-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-307020"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs109"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.018"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0254-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.03.004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.05.044"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.08.049"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2019.04.012"},{"key":"e_1_2_8_16_1","unstructured":"Healthcare Cost and Utilization Project.NRD overview.https:\/\/www.hcup-us.ahrq.gov\/nrdoverview.jsp. 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