{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:37:17Z","timestamp":1762508237886,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The authors aimed to investigate the benefits and risks of catheter\u2010directed thrombolysis (CDT) in acute deep venous thrombosis (DVT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The role of CDT in the management of DVT is evolving. Data on CDT versus anticoagulation alone in acute DVT is sparse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic review and meta\u2010analysis of published studies that compared CDT to anticoagulation alone in patients with acute DVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 11 studies (four randomized control trials [RCTs] and seven observational studies) with a total of 8,737 patients. During hospital stay, patients who received CDT had higher odds of major bleeding (2.5% vs. 1.6%; OR 1.46, 95% CI [1.07, 1.98], <jats:italic>p<\/jats:italic> = .02), blood transfusion (10.8% vs. 6.2%; OR 1.8, 95% CI [1.52, 2.13], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and thromboembolism (15.5% vs. 10%; OR 1.67, 95% CI [1.47, 1.91], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) compared with anticoagulation alone. At 6\u2010month follow\u2010up, patients who received CDT had higher venous patency (71.1% vs. 37.7%; OR 5.49, 95% CI [2.63, 11.5], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and lower postthrombotic syndrome (PTS; 27% vs. 40.7%; OR 0.44, 95% CI [0.22, 0.86], <jats:italic>p<\/jats:italic> = .02). During a mean follow\u2010up duration of 30.5\u2009\u00b1\u200928\u2009months, CDT group continued to have higher venous patency (79.6% vs. 71.8%; OR 3.79, 95% CI [1.54, 9.32], <jats:italic>p<\/jats:italic> = .004) and lower PTS (44.7% vs. 50.5%; OR 0.43, 95% CI [0.23, 0.78], <jats:italic>p<\/jats:italic> = .006), but no difference in thromboembolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with anticoagulation alone, CDT for patients with acute DVT was associated with a higher risk of complications, but a higher rate of venous patency and lower risk of postthrombotic syndrome at 2.5\u2009years follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29226","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T21:54:52Z","timestamp":1600293292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Outcomes with <scp>catheter\u2010directed<\/scp> thrombolysis compared with anticoagulation alone in patients with acute deep venous thrombosis"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7600-4049","authenticated-orcid":false,"given":"Bishoy","family":"Abraham","sequence":"first","affiliation":[{"name":"Department of Medicine Ascension Saint John Hospital  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9395-0851","authenticated-orcid":false,"given":"Ramy","family":"Sedhom","sequence":"additional","affiliation":[{"name":"Department of Medicine Albert Einstein Medical Center  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Megaly","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute Abbott Northwestern Hospital  Minneapolis Minnesota"},{"name":"Division of Cardiovascular Medicine Department of Medicine, Hennepin Healthcare  Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-8030","authenticated-orcid":false,"given":"Marwan","family":"Saad","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute The Warren Alpert Medical School of Brown University  Providence Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman","family":"Elbadawi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Texas Medical Branch  Galveston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9853-7591","authenticated-orcid":false,"given":"Islam Y.","family":"Elgendy","sequence":"additional","affiliation":[{"name":"Division of Cardiology Massachusetts General Hospital and Harvard Medical School  Boston 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