{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:30:18Z","timestamp":1790371818841,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the Usefulness of oral anticoagulation therapy (OAT) in patients with coronary artery aneurysm (CAA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on the most adequate antithrombotic CAA management is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients included in CAAR (Coronary Artery Aneurysm Registry, Clinical Trials.gov: NCT02563626) were selected. Patients were divided in OAT and non\u2010OAT groups, according to anticoagulation status at discharge and 2:1 propensity score matching with replacement was performed. The primary endpoint of the analysis was a composite and mutual exclusive endpoint of myocardial infarction, unstable angina (UA), and aneurysm thrombosis (coronary ischemic endpoint). Net adverse clinical events, major adverse cardiovascular events, their single components, cardiovascular death, re\u2010hospitalizations for heart failure, stroke, aneurysm thrombosis, and bleeding were the secondary ones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One thousand three hundred thirty\u2010one patients were discharged without OAT and 211 with OAT. In the propensity\u2010matched sample (390 patients in the non\u2010OAT group, 195 patients in the OAT group), after 3 years of median follow\u2010up (interquartile range 1\u20136 years), the rate of the primary endpoint (coronary ischemic endpoint) was significantly less in the OAT group as compared to non\u2010OAT group (8.7 vs. 17.2%, respectively; <jats:italic>p<\/jats:italic> = .01), driven by a significant reduction in UA (4.6 vs. 10%, <jats:italic>p<\/jats:italic> &lt; .01) and aneurysm thrombosis (0 vs. 3.1%, <jats:italic>p<\/jats:italic> = .03), along with a non\u2010significant reduction in MI (4.1 vs. 7.7%, <jats:italic>p<\/jats:italic> = .13). A non\u2010significant increase in bleedings, mainly BARC type 1 (55%), was found in the OAT\u2010group (10.3% in the non\u2010OAT vs. 6.2% in the OAT group, <jats:italic>p<\/jats:italic> = .08).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OAT decreases the composite endpoint of UA, myocardial infarction, and aneurysm thrombosis in patients with CAA, despite a non\u2010significant higher risk of bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29243","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T08:00:36Z","timestamp":1600070436000},"page":"864-871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Usefulness of oral anticoagulation in patients with coronary aneurysms: Insights from the CAAR registry"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-9317","authenticated-orcid":false,"given":"Fabrizio","family":"D'Ascenzo","sequence":"first","affiliation":[{"name":"Cardiology, Citt\u00e0 della Salute e della Scienza Molinette Hospital  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-1507","authenticated-orcid":false,"given":"Andrea","family":"Saglietto","sequence":"additional","affiliation":[{"name":"Cardiology, Citt\u00e0 della Salute e della Scienza Molinette Hospital  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Ramakrishna","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Anesthesiology Mayo Clinic Rochester  Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Andreis","sequence":"additional","affiliation":[{"name":"Cardiology, Citt\u00e0 della 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Liebetrau","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kerckhoff Heart and Thorax Center  Bad Nauheim Germany"},{"name":"Partner Site Rhein\u2010Main DZHK (German Centre for Cardiovascular Research)  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Alfonso\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Cardiology Division Instituto de Cardiolog\u00eda y Cirug\u00eda Cardiovascular  La Habana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Bagur","sequence":"additional","affiliation":[{"name":"Interventional Cardiology University Hospital, London Health Sciences Centre  London Ontario 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