{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:22:19Z","timestamp":1771456939640,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T00:00:00Z","timestamp":1599264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We sought to evaluate the feasibility and safety of carotid access transcatheter aortic valve replacement (TAVR) by performing a meta\u2010analysis of published cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Several case series and regional data have provided initial basis for carotid access TAVR in patients with prohibitive femoral approach. We performed this meta\u2010analysis to provide further evidence of feasibility and safety of carotid TAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed, EMBASE, CINAHL, and Cochrane CENTRAL for any study on carotid access TAVR involving \u2a7e5 patients since inception till March 1, 2020. Random\u2010effects model was used to compute overall effects. The outcomes analyzed were all\u2010cause mortality, Transient ischemic attack (TIA)\/stroke, need for permanent pacemaker (PPM) implantation, pericardial tamponade, access site complications, major bleeding, and length of stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a total of 17 retrospective studies (<jats:italic>n<\/jats:italic> = 2082) with a median follow\u2010up of 1 month. Mean age of the patient was 80\u2009years. Mean Euroscore and STS scores were 15\u2009\u00b1\u20096.2 and 7.9\u2009\u00b1\u20093.3, respectively. The procedural success rate was 99%. The rate of all\u2010cause mortality was 6.7% (range 4.6\u20139.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001, I<jats:sup>2<\/jats:sup> = 67%). Incidence of TIA\/stroke was 3.9% (range 3.1\u20134.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001, I<jats:sup>2<\/jats:sup> = 0%) and PPM implantation was 16.7% (range 12.5\u201321.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001, I<jats:sup>2<\/jats:sup> = 56%). Rate of pericardial tamponade, vascular complication, and major bleeding were 1.7, 2.5, and 7%, respectively. Average length of hospital stay was 7.7\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results show that transcarotid approach is a feasible option in patients with prohibitive femoral access for TAVR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29244","type":"journal-article","created":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T18:08:41Z","timestamp":1599329321000},"page":"723-733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Carotid access for transcatheter aortic valve replacement: A meta\u2010analysis"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1475-6004","authenticated-orcid":false,"given":"Sharan Prakash","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Cardiology Garden City Hospital  Garden City Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Division of Hospital Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Ghuneim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Garden City Hospital  Garden City Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Harder","sequence":"additional","affiliation":[{"name":"Department of Cardiology Garden City Hospital  Garden City Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shukri","family":"David","sequence":"additional","affiliation":[{"name":"Division of Cardiology Ascension Providence Hospital  Southfield Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishit","family":"Choksi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Garden City Hospital  Garden City Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Snigdha","family":"Kondur","sequence":"additional","affiliation":[{"name":"Department of Cardiology Garden City Hospital  Garden City Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swathi","family":"Kambhatla","sequence":"additional","affiliation":[{"name":"Department of Cardiology Garden City Hospital  Garden City Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujata","family":"Kambhatla","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Garden City Hospital  Garden City Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Kondur","sequence":"additional","affiliation":[{"name":"Department of Cardiology Garden City Hospital  Garden City Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.07.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816885"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.12.057"},{"key":"e_1_2_10_6_1","unstructured":"Study Quality Assessment Tools. 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