{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T14:57:47Z","timestamp":1771685867817,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We compared the long\u2010term outcomes of percutaneous coronary intervention with second\u2010generation drug\u2010eluting stents (PCI\u2010DES) and coronary artery bypass graft surgery (CABG) with the left internal mammary artery in stable angina patients with isolated single\u2010vessel proximal left anterior descending artery (pLAD) disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Long\u2010term outcomes of second\u2010generation PCI\u2010DES and CABG in isolated pLAD lesions have not been extensively studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 631 PCI\u2010DES patients and 379 CABG patients. Unadjusted and adjusted hazard ratios (HRs) were derived for major adverse cardiac events (MACEs), their components (cardiac death, nonfatal myocardial infarction [MI] not attributed to a non\u2010target vessel, target\u2010lesion revascularization), and patient\u2010related outcome (PRO, composed of all\u2010cause mortality, any MI, any revascularization).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the unadjusted and adjusted analyses, no significant difference was observed between the two groups at follow\u2010up (mean:4.6\u2009\u00b1\u20092.5\u2009years) for MACEs (HR: 1.45, 95% CI: 0.92\u20132.28, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.11; HR:1.43, 95% CI: 0.91\u20132.26, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.13), PRO (HR: 1.18, 95%CI: 0.86\u20131.61, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.30; HR: 1.18, 95% CI: 0.86\u20131.62, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.31), cardiac death (HR: 0.97, 95% CI: 0.46\u20132.05, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.93; HR: 0.79, 95% CI: 0.36\u20131.72, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.56) and MI (HR: 1.43, 95% CI: 0.49\u20134.13, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.51; HR: 1.57, 95% CI: 0.53\u20134.64, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.42). Compared with CABG, PCI\u2010DES had a borderline significantly greater risk of repeat revascularization (HR: 1.99, 95% CI: 1.00\u20133.94, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.05; HR: 1.95, 95% CI: 0.98\u20133.9, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.06). Angina recurred more often after PCI (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), whereas more arrhythmias developed after CABG (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.02). PCI\u2010DES resulted in fewer in\u2010hospital complications (p\u2009&lt;\u2009.001) and shorter hospitalizations (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The long\u2010term clinical outcomes of second\u2010generation PCI\u2010DES and CABG in patients with stable angina and isolated pLAD disease were comparable.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29247","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T13:24:55Z","timestamp":1598880295000},"page":"447-457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010term clinical outcomes of coronary artery bypass graft surgery compared to those of percutaneous coronary intervention with second generation drug eluting stents in patients with stable angina and an isolated lesion in the proximal left anterior descending artery"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5277-1953","authenticated-orcid":false,"given":"Ioannis L.","family":"Matsoukis","sequence":"first","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics Athens Medical School  Athens Greece"},{"name":"1st Cardiology Department Athens Medical School, Hippokration General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8052-6739","authenticated-orcid":false,"given":"Antonios","family":"Karanasos","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Athens Medical School, Hippokration General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrysoula","family":"Patsa","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Athens Medical School, Hippokration General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Anousakis\u2010Vlachochristou","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Athens Medical School, Hippokration General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Triantafyllou","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department Hippokration General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Kantzanou","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics Athens Medical School  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0022-0332","authenticated-orcid":false,"given":"Maria","family":"Drakopoulou","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Athens Medical School, Hippokration General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleftherios","family":"Tsiamis","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Athens Medical School, Hippokration General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Latsios","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Athens Medical School, Hippokration General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8516-1177","authenticated-orcid":false,"given":"Andreas","family":"Synetos","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Athens Medical School, Hippokration General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni Th","family":"Petridou","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics Athens Medical School  Athens Greece"},{"name":"Clinical Epidemiology Unit Karolinska Institute  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitris","family":"Tousoulis","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Athens Medical School, Hippokration General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2946-344X","authenticated-orcid":false,"given":"Konstantinos","family":"Toutouzas","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Athens Medical School, Hippokration General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1810170104"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.112.970954"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.111.964320"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.916"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.12.062"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.06.041"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.08.006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt137"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4065\/75.11.1116"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.074"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20238"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.032"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21246"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39106.476215.BE"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2008.07.001"},{"key":"e_1_2_7_18_1","first-page":"e166","article-title":"ACC\/AHA\/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology\/American Heart Association task force on practice guidelines (ACC\/AHA\/SCAI writing committee to update 2001 guidelines for percutaneous coronary intervention)","volume":"113","author":"Smith SJ","year":"2006","journal-title":"Circulation"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.11.031"},{"key":"e_1_2_7_20_1","first-page":"386","article-title":"Choosing a perspective on mortality with DAPT","volume":"37","author":"Parker WA","year":"2016","journal-title":"Eur Heart J"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211585"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr305"},{"key":"e_1_2_7_23_1","first-page":"468","article-title":"Coronary artery bypass surgery compared with percutaneous coronary intervention for proximal left anterior descending artery treatment in patients with acute coronary syndrome: analysis from the ACUITY trial","volume":"27","author":"Mennuni M","year":"2015","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.24512"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.03.095"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S30122"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.01.044"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I10A184"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.29247","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T12:14:29Z","timestamp":1692706469000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.29247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,31]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/ccd.29247"],"URL":"https:\/\/doi.org\/10.1002\/ccd.29247","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,31]]},"assertion":[{"value":"2020-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}