{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:42:43Z","timestamp":1761864163849,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Percutaneous mitral valve repair (PMVR), such as MitraClip, is performed on high\u2010risk patients and involves hemodynamic alternations that may cause acute kidney injury (AKI). We aimed to evaluate the incidence of AKI, predictors for developing AKI and the correlation with mortality after MitraClip.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective analysis of collected data from patients who underwent PMVR in two tertiary medical centers in Israel to identify factors associated with AKI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population included 163 patients. The median age was 77\u2009years; 60.7% of patients were male. The median eGFR significantly decreased post\u2010procedure from 49 (35\u201372) to 47.8 (31\u201365.5) ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001). Forty\u2010seven patients (29%) developed AKI. None of the patients who developed AKI required hemodialysis. Predictors of AKI included: baseline eGFR \u226430\u2009ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>, severity of residual MR, TMPG&gt;5\u2009mmHg, diuretic use, and re\u2010do procedures. Among the patients who developed AKI there was an improvement in kidney function during follow\u2010up, and creatinine levels significantly decreased from a peak mean creatinine of 179.5 (143\u2013252) mmol\/l to 136 (92\u2013174) mmol\/l (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001). However, 19% (9 out of 47) of patients experienced partial recovery and their creatinine level, when compared to their baseline, remained elevated. One\u2010year survival showed a trend for increased mortality among patients who developed AKI (86.2% vs. 80.9%, <jats:italic>p<\/jats:italic>\u00a0=\u2009.4), and patients who developed AKI that persisted had increased 1\u2010year mortality compared with patients that had recovered their kidney function (86.8% vs. 55.6%, <jats:italic>p<\/jats:italic>\u00a0=\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of AKI after MitraClip is high. AKI is reversible in most patients; however, the persistence of kidney injury is associated with increased 1\u2010year mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29250","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T14:47:04Z","timestamp":1598885224000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Acute kidney injury after MitraClip implantation in patients with severe mitral regurgitation"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4405-4698","authenticated-orcid":false,"given":"Ivaylo","family":"Tonchev","sequence":"first","affiliation":[{"name":"Heart Institute Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Heberman","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alona","family":"Peretz","sequence":"additional","affiliation":[{"name":"Heart Institute Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8313-3789","authenticated-orcid":false,"given":"Anna Turyan","family":"Medvedovsky","sequence":"additional","affiliation":[{"name":"Heart Institute Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Israel","family":"Gotsman","sequence":"additional","affiliation":[{"name":"Heart Institute Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonatan","family":"Rashi","sequence":"additional","affiliation":[{"name":"Heart Institute Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lion","family":"Poles","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorel","family":"Goland","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gidon Y.","family":"Perlman","sequence":"additional","affiliation":[{"name":"Heart Institute Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haim D.","family":"Danenberg","sequence":"additional","affiliation":[{"name":"Heart Institute Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronen","family":"Beeri","sequence":"additional","affiliation":[{"name":"Heart Institute 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