{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:40:05Z","timestamp":1747147205614,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004362","name":"Schweizerische Herzstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study compares procedural and late clinical outcomes of left atrial appendage closure (LAAC) with Amplatzer devices as a single versus a combined procedure with other structural or coronary interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Multiple cardiac conditions are frequent among elderly patients and invite simultaneous treatment to ensure a favorable patient outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>559 consecutive patients (73.3\u2009\u00b1\u200911.1\u2009years) underwent LAAC with Amplatzer devices at two centres (Bern and Zurich university hospitals, Switzerland) either as a single procedure or combined with other interventions. The primary safety endpoint was a composite of major peri\u2010procedural complications and major bleeding at follow\u2010up, the primary efficacy endpoint included stroke, systemic embolism, and cardiovascular\/unexplained death. All event rates are reported per 100 patient\u2010years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 263 single and 296 combined procedures with percutaneous coronary interventions (47.6%), closure of an atrial septal defect (8.4%) or a patent foramen ovale (36.5%), transcatheter aortic valve implantation (10.1%), mitral clipping (4.1%), atrial fibrillation ablation (8.8%), or another procedure (3.0%) were analyzed. Device success (96.6% [single] vs. 99.0% [combined], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.08) did not differ between the groups. After a mean follow\u2010up of 2.6\u2009\u00b1\u20091.5 vs. 2.5\u2009\u00b1\u20091.5\u2009years and a total of 1,422 patient\u2010years, the primary efficacy (40\/677, 5.9% [single] vs. 37\/745, 5.0% [combined]; HR, 1.2, 95% CI, 0.8\u20131.9, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.44), as well as the primary safety endpoint (25\/677, 3.7% vs 28\/745, 3.8%; HR, 1.0, 95% CI, 0.6\u20131.8, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.89) were comparable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LAAC with Amplatzer devices combined with structural, coronary, and electrophysiological procedures offers procedural feasibility and safety, as well as long\u2010term efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29271","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T10:36:23Z","timestamp":1601202983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Amplatzer left atrial appendage closure: Single versus combined procedures"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6814-5236","authenticated-orcid":false,"given":"Caroline","family":"Kleinecke","sequence":"first","affiliation":[{"name":"Cardiology Klinikum Lichtenfels  Lichtenfels Germany"},{"name":"Cardiology, Klinikum Hochrhein  Waldshut\u2010Tiengen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Buffle","sequence":"additional","affiliation":[{"name":"Cardiology, Cardiovascular Department University Hospital of Bern  Bern 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