{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:50:09Z","timestamp":1784685009872,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To systematically review relevant literature regarding cardiovascular outcomes of large\u2010bore axillary arterial access via percutaneous and surgical approaches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with severe peripheral arterial disease (PAD) undergoing cardiac interventions, large\u2010bore femoral access may be prohibitive. The axillary artery provides an alternative vascular access for transcatheter aortic valve replacement (TAVR) or mechanical circulatory support. There have been limited comparisons of percutaneous transaxillary (pTAX) approach with the more traditional surgical transaxillary (sTAX) approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pubmed and Medline databases were queried through January 2019 for studies describing pTAX or sTAX approaches with TAVR or Impella insertion. Primary outcomes were access\u2010related mortality, 30\u2010day mortality, stroke, major vascular complications, and major bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and fifty five studies were reviewed, with additional unpublished data from 1 institution. Twenty\u2010two studies met the inclusion criteria. Patient data was heterogeneous, with 69% TAVR and 31% Impella use in the pTAX group, and 96% TAVR and 4% Impella use in the sTAX group. There was more cardiogenic shock in the pTAX group. When compared to surgical approach, the percutaneous approach had similar 30\u2010day mortality for TAVR (5.6% vs 4.6%, <jats:italic>OR<\/jats:italic> non\u2010significant) and Impella (43.4% vs 38.6%, <jats:italic>OR<\/jats:italic> non\u2010significant), similar stroke rates (4.3% vs 4.2%, <jats:italic>OR<\/jats:italic> non\u2010significant), similar major vascular complications (2.8% vs 2.3%, <jats:italic>OR<\/jats:italic> non\u2010significant) and less major bleeding (2.7% vs 17.9%, <jats:italic>OR<\/jats:italic> significant).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Data suggests large\u2010bore pTAX access has similar 30\u2010day mortality, stroke rates, and major vascular complications as sTAX access, with less major bleeding. Additional studies are needed to validate results.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29273","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T07:30:41Z","timestamp":1600414241000},"page":"1481-1488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Percutaneous <scp>large\u2010bore<\/scp> axillary access is a safe alternative to surgical approach: A systematic review"],"prefix":"10.1002","volume":"96","author":[{"given":"Geoffrey","family":"Southmayd","sequence":"first","affiliation":[{"name":"Division of Cardiology Emory University School of Medicine  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azizul","family":"Hoque","sequence":"additional","affiliation":[{"name":"Division of Cardiology Emory University School of Medicine  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Kaki","sequence":"additional","affiliation":[{"name":"Division of Cardiology Ascension St. John Hospital  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Tayal","sequence":"additional","affiliation":[{"name":"Division of Cardiology RWJ Barnabas Health, Newark Beth Israel Medical Center  Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8258-1600","authenticated-orcid":false,"given":"S. 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