{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T01:01:12Z","timestamp":1780794072566,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The study aims to compare the hemodynamic and clinical outcomes of the SAPIEN 3 Ultra (S3\u2010Ultra) with the SAPIEN 3 (S3) system in patients who underwent transfemoral transcatheter aortic valve replacement (TF\u2010TAVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The new balloon\u2010expandable S3\u2010Ultra system incorporates new features to reduce paravalvular leakage (PVL). However, the data after the S3\u2010Ultra implantation is very limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 282 consecutive patients who underwent TF\u2010TAVR with the S3\u2010Ultra and the S3 were evaluated. The primary outcome of this study was to compare the incidence of \u2265mild PVL after the S3\u2010Ultra and S3 implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between June 2017 and November 2019, 141 patients with the S3\u2010Ultra and 141 patients with the S3 were identified with similar baseline and preprocedural imaging characteristics (mean age: 79.6\u2009\u00b1\u20096.7\u2009years and mean aortic annulus area: 492.5\u2009\u00b1\u200991.2\u2009mm<jats:sup>2<\/jats:sup>). In total, 83 patients (29.4%) were treated with 29\u2010mm valve. Predischarge echocardiography demonstrated a significantly lower incidence of \u2265mild PVL (the total cohort: 7.2 vs. 22.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001, and the cohort excluding 29\u2010mm valve: 4.0 vs. 21.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03) for the S3\u2010Ultra. The S3\u2010Ultra system, especially 20\u2010, 23\u2010, and 26\u2010mm valve, was associated with significantly lower risk of \u2265mild PVL compared with the S3 system in multivariate analysis. There were no significant differences in clinical outcomes at 30\u2010day between these groups, except for the lower incidence of major vascular complication (4.5 vs. 11.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.05) in patients with the S3\u2010Ultra.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this registry, the S3\u2010Ultra system performed superiorly to the S3, as demonstrated by reduced \u2265mild PVL, with comparable safety.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29281","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T16:47:40Z","timestamp":1600879660000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Hemodynamic comparison of transcatheter aortic valve replacement with the SAPIEN 3 Ultra versus SAPIEN 3: The HomoSAPIEN registry"],"prefix":"10.1002","volume":"97","author":[{"given":"Noriaki","family":"Moriyama","sequence":"first","affiliation":[{"name":"Department of Cardiology, Heart and Lung Center Helsinki University and Helsinki University Central Hospital  Helsinki Finland"},{"name":"Department of Cardiology and Catheterization Laboratories Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Lehtola","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1562-9437","authenticated-orcid":false,"given":"Hirokazu","family":"Miyashita","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Lung Center Helsinki University and Helsinki University Central Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarkko","family":"Piuhola","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Niemel\u00e4","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Laine","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Lung Center Helsinki University and Helsinki University Central Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400590"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.03.014"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816885"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-00541"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.115.002541"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.04.005"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.10.014"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.001"},{"key":"e_1_2_10_12_1","unstructured":"Online STS Adult Cardiac Surgery Risk Calculator.http:\/\/riskcalc.sts.org\/stswebriskcalc\/calculate. 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