{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:38:42Z","timestamp":1763037522368,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to investigate the invasive hemodynamic changes with transcatheter mitral valve replacement (TMVR) in patients with severe mitral stenosis due to severe mitral annular calcification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The hemodynamic response to TMVR in patients with mitral stenosis related to degenerative mitral annular calcification has not been fully elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted retrospective review of patients who underwent successful transseptal TMVR with balloon\u2010expandable valves for symptomatic severe mitral stenosis due to mitral annular calcification at our institution between January 2014 and February 2020. Invasive hemodynamic measurements were obtained both before valve implantation (predeployment) and after (postdeployment).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen patients (age 72\u2009\u00b1\u200910\u2009years, 44% female) were included for the analysis. There was a significant reduction in mean left atrial pressure (23.7\u2009\u00b1\u20095.6\u2009mmHg versus 20.6\u2009\u00b1\u20094.8\u2009mmHg; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01), left atrial v\u2010wave (mean 39.3\u2009\u00b1\u200910.2\u2009mmHg versus 32.9\u2009\u00b1\u20099.9\u2009mmHg; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01), and an increase in systemic mean blood pressure (72.6\u2009mmHg \u00b111.2 versus 79.5\u2009\u00b1\u20099.9\u2009mmHg; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02) postdeployment compared to predeployment. Patients who had symptom improvement at 30\u2010day follow\u2010up tended to have greater reduction in mean left atrial pressure (4.4\u2009\u00b1\u20094.4\u2009mmHg versus 0.5\u2009\u00b1\u20095.2\u2009mmHg; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.16) and v\u2010wave (8.6\u2009\u00b1\u20099.0\u2009mmHg versus 0.7\u2009\u00b1\u20098.4\u2009mmHg; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.10) compared to those who did not experience improvement of symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Transseptal TMVR for severe mitral stenosis due to mitral annular calcification is associated with reductions in mean left atrial pressure and left atrial v\u2010wave, and an increase in systemic arterial pressure.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29285","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T17:13:47Z","timestamp":1601572427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hemodynamic response to transseptal transcatheter mitral valve replacement in patients with severe mitral stenosis due to severe mitral annular calcification"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8985-8756","authenticated-orcid":false,"given":"Naoki","family":"Misumida","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorin V.","family":"Pislaru","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Alkhouli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charanjit S.","family":"Rihal","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6082-5379","authenticated-orcid":false,"given":"Mackram F.","family":"Eleid","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.09.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90214-0"},{"key":"e_1_2_8_4_1","first-page":"255","article-title":"Stiff left atrial syndrome","volume":"4","author":"Pilote L","year":"1988","journal-title":"Can J Cardiol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.040095"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-013-0207-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.04.022"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008425"},{"key":"e_1_2_8_9_1","first-page":"10","article-title":"Acute changes in left atrial pressure after MitraClip are associated with improvement in 6\u2010minute walk distance","volume":"004856","author":"Maor E","year":"2017","journal-title":"Circ Cardiovasc Interv"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28149"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.02.041"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.054"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.11.018"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.187088"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.07.051"}],"container-title":["Catheterization and Cardiovascular 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