{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:34:22Z","timestamp":1773797662013,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T00:00:00Z","timestamp":1601683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Baseline conduction abnormalities are known risk factors for permanent pacemaker (PPM) implantation after transcatheter aortic valve replacement (TAVR). We sought to determine the impact of baseline right bundle branch block (RBBB), left bundle branch block (LBBB), left anterior hemiblock (LAHB), first\u2010degree atrioventricular block (AVB) and atrial fibrillation\/flutter (AF) on TAVR outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients who underwent transfemoral TAVR with SAPIEN\u20103 (S3) were included. We excluded patients with prior PPM, nontransfemoral access or valve\u2010in\u2010valve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 886 patients, baseline RBBB was seen in 15.9%, LBBB in 6.3%, LAHB in 6.2%, first\u2010degree AVB in 26.3% and AF in 37.5%. The rate of 30\u2010day PPM was 10.1%. Baseline RBBB (OR 4.005; 95% CI 2.386\u20136.723; <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001) and first\u2010degree AVB (OR 1.847; 95% CI 1.133\u20133.009; <jats:italic>p<\/jats:italic>\u00a0=\u2009.014) were independent predictors of 30\u2009day PPM. LAHB also resulted in higher PPM rates but only in unadjusted analysis (21.8% vs. 9.4%; <jats:italic>p<\/jats:italic>\u00a0=\u2009.003). Baseline LBBB and AF were associated with lower left ventricular ejection fraction (LVEF) at both baseline and 1\u00a0year after TAVR. However, \u0394 LVEF over time were noted to be similar with baseline LBBB (1.8% vs. 1.4%; <jats:italic>p<\/jats:italic>\u00a0=\u2009.809) and AF (1.1% vs. 1.7%; <jats:italic>p<\/jats:italic>\u00a0=\u2009.458). Moreover, baseline AF was also associated with higher stroke\/transient ischemic attack (TIA) at 1\u00a0year (4.4% vs. 1.8%; <jats:italic>p<\/jats:italic>\u00a0=\u2009.019), 1\u2010year major adverse cardiac and cerebrovascular events (MACCE) (19.5% vs. 13.3%; <jats:italic>p<\/jats:italic>\u00a0=\u2009.012) and 2\u00a0year mortality (23.5% vs. 15.2%; <jats:italic>p<\/jats:italic>\u00a0=\u2009.016). None of the other baseline conduction defects affected long\u2010term mortality or MACCE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our S3 TAVR population, baseline RBBB and first\u2010degree AVB predicted higher PPM risk. Prior LBBB and AF were associated with lower LVEF at both baseline and 1 year. Lastly, preexisting AF was associated with higher rates of mortality, stroke\/TIA, and MACCE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29309","type":"journal-article","created":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T13:06:47Z","timestamp":1601730407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of baseline conduction abnormalities on outcomes after transcatheter aortic valve replacement with <scp>SAPIEN<\/scp>\u20103"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1763-9340","authenticated-orcid":false,"given":"Yasser","family":"Sammour","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1664-7875","authenticated-orcid":false,"given":"Arnav","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rama Dilip","family":"Gajulapalli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4778-5461","authenticated-orcid":false,"given":"Hassan","family":"Lak","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanchit","family":"Chawla","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinjal","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron","family":"Incognito","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"Popovic","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaldoun","family":"Tarakji","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular 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