{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:24:50Z","timestamp":1777861490068,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Redo surgical mitral valve replacement (SMVR) is the current standard of care for patients with failed bioprosthetic mitral valve (MV). Transcatheter mitral valve\u2010in\u2010valve replacement (TMViV) is arising as an alternative to SMVR in high risk patients. We sought to evaluate procedural safety, early and mid\u2010term outcomes of patients who underwent transseptal TMViV (TS\u2010TMViV), transapical TMViV (TA\u2010TMViV), or redo\u2010SMVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified patients with failed bioprosthetic MV who underwent TS\u2010TMViV, TA\u2010TMViV, or SMVR at four Italian Centers. Clinical and echocardiographic data were codified according to Mitral Valve Academic Research Consortium definition (MVARC), except for significant valve stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between December 2012 and September 27, 2019 patients underwent TS\u2010TMViV, 22 TA\u2010TMViV, and 29 redo\u2010SMVR. TS\u2010TMViV and TA\u2010TMViV patients presented higher mean age and surgical risk scores compared with SMVR group (77.8\u2009\u00b1\u200912\u2009years, 77.3\u2009\u00b1\u20097.3\u2009years, 67.8\u2009\u00b1\u20099.4\u2009years, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001; STS PROM 8.5\u2009\u00b1\u20097.2; 8.9\u2009\u00b1\u20094.7; 3.6\u2009\u00b1\u20092.6, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). TS\u2010TMViV procedure was associated with shorter intensive care unit time and total length of stay (LOS) compared with TA\u2010TMViV and SMVR group. There were no differences in MVARC procedural success at 30\u2010days (74.1, 72.7, and 51.7%, <jats:italic>p<\/jats:italic> = .15) and one\u2010year all\u2010cause mortality between groups (14.8, 18.2, and 17.2%, <jats:italic>p<\/jats:italic> = 1.0). MV mean gradient was similar between TS\u2010TMViV, TA\u2010TMViV, and SMVR groups at 30\u2009days and 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For the selected patients, TS\u2010TMViV and TA\u2010TMViV are to be considered a valid alternative to redo\u2010SMVR with comparable 1\u2010year survival. TS\u2010TMViV is the less invasive strategy and has the advantage of shortening the LOS compared with TA\u2010TMViV.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29324","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T19:10:06Z","timestamp":1602616206000},"page":"714-722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Surgical redo versus transseptal or transapical transcatheter mitral valve\u2010in\u2010valve implantation for failed mitral valve bioprosthesis"],"prefix":"10.1002","volume":"97","author":[{"given":"Federico","family":"Simonetto","sequence":"first","affiliation":[{"name":"Interventional Cardiology, Department of Cardiothoracic and Vascular Science Ospedale dell'Angelo  Venice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2552-0259","authenticated-orcid":false,"given":"Paola A. M.","family":"Purita","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, Department of Cardiothoracic and Vascular Science Ospedale dell'Angelo  Venice Italy"},{"name":"Cardiology Division Ospedale Civile di Mirano  Mirano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5909-6957","authenticated-orcid":false,"given":"Massimiliano","family":"Malerba","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ca' Foncello Hospital  Treviso Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Barbierato","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, Department of Cardiothoracic and Vascular Science Ospedale dell'Angelo  Venice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Pascotto","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, Department of Cardiothoracic and Vascular Science Ospedale dell'Angelo  Venice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Mangino","sequence":"additional","affiliation":[{"name":"Cardiac Surgery, Department of Cardiothoracic and Vascular Science Ospedale dell'Angelo  Venice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Zanchettin","sequence":"additional","affiliation":[{"name":"Cardiac Surgery, Department of Cardiothoracic and Vascular Science Ospedale dell'Angelo  Venice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5055-2917","authenticated-orcid":false,"given":"Giuseppe","family":"Tarantini","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gino","family":"Gerosa","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto","family":"D'Onofrio","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Cernetti","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ca' Foncello Hospital  Treviso Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Favero","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ca' Foncello Hospital  Treviso Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Daniotti","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ca' Foncello Hospital  Treviso Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Minniti","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Ca' Foncello Hospital  Treviso Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Caprioglio","sequence":"additional","affiliation":[{"name":"Division of Cardiology S. Bortolo Hospital  Vicenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Erente","sequence":"additional","affiliation":[{"name":"Division of Cardiology S. Bortolo Hospital  Vicenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Hinna Danesi","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery S. 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