{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T19:08:00Z","timestamp":1776020880761,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002373"],"award-info":[{"award-number":["UL1TR002373"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32 HL 007936"],"award-info":[{"award-number":["T32 HL 007936"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Compare lung parenchymal and pulmonary artery (PA) growth and hemodynamics following early and delayed PA stent interventions for treatment of unilateral branch PA stenosis (PAS) in swine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>How the pulmonary circulation remodels in response to different durations of hypoperfusion and how much growth and function can be recovered with catheter directed interventions at differing time periods of lung development is not understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 18 swine were assigned to four groups: Sham (<jats:italic>n\u2009=<\/jats:italic> 4), untreated left PAS (LPAS) (<jats:italic>n\u2009=<\/jats:italic> 4), early intervention (EI) (<jats:italic>n\u2009=<\/jats:italic> 5), and delayed intervention (DI) (<jats:italic>n\u2009=<\/jats:italic> 5). EI had left pulmonary artery (LPA) stenting at 5 weeks (6\u2009kg) with redilation at 10\u2009weeks. DI had stenting at 10\u2009weeks. All underwent right heart catheterization, computed tomography, magnetic resonance imaging, and histology at 20\u2009weeks (55\u2009kg).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>EI decreased the extent of histologic changes in the left lung as DI had marked alveolar septal and bronchovascular abnormalities (<jats:italic>p<\/jats:italic> = .05 and <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05 vs. sham) that were less prevalent in EI. EI also increased left lung volumes and alveolar counts compared to DI. EI and DI equally restored LPA pulsatility, R heart pressures, and distal LPA growth. EI and DI improved, but did not normalize LPA stenosis diameter (LPA\/DAo ratio: Sham 1.27\u2009\u00b1\u20090.11\u2009mm\/mm, DI 0.88\u2009\u00b1\u20090.10\u2009mm\/mm, EI 1.01\u2009\u00b1\u20090.09\u2009mm\/mm) and pulmonary blood flow distributions (LPA\u2010flow%: Sham 52\u2009\u00b1\u20095%, LPAS 7\u2009\u00b1\u20092%, DI 44\u2009\u00b1\u20093%, EI 40\u2009\u00b1\u20092%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this surgically created PAS model, EI was associated with improved lung parenchymal development compared to DI. Longer durations of L lung hypoperfusion did not detrimentally affect PA growth and R heart hemodynamics. Functional and anatomical discrepancies persist despite successful stent interventions that warrant additional investigation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29326","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T14:24:57Z","timestamp":1602858297000},"page":"1454-1464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pulmonary artery and lung parenchymal growth following early versus delayed stent interventions in a swine pulmonary artery stenosis model"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1190-7196","authenticated-orcid":false,"given":"Ryan","family":"Pewowaruk","sequence":"first","affiliation":[{"name":"Biomedical Engineering University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Hermsen","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Wisconsin\u2013Madison  Madison Wisconsin USA"},{"name":"Cardiovascular Surgery University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cody","family":"Johnson","sequence":"additional","affiliation":[{"name":"Radiology University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Erdmann","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Pettit","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Aesif","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Wisconsin\u2013Madison  Madison Wisconsin USA"},{"name":"Pathology University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Carter","family":"Ralphe","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Wisconsin\u2013Madison  Madison Wisconsin USA"},{"name":"Pediatrics, Division of Cardiology University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Francois","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Wisconsin\u2013Madison  Madison Wisconsin USA"},{"name":"Radiology University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Rold\u00e1n\u2010Alzate","sequence":"additional","affiliation":[{"name":"Biomedical Engineering University of Wisconsin\u2013Madison  Madison Wisconsin USA"},{"name":"Radiology University of Wisconsin\u2013Madison  Madison Wisconsin USA"},{"name":"Mechanical Engineering University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9736-3569","authenticated-orcid":false,"given":"Luke","family":"Lamers","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Wisconsin\u2013Madison  Madison Wisconsin USA"},{"name":"Pediatrics, Division of Cardiology University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/prrv.2000.0071"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2004.11.009"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02714-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00316-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00095-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.28.2.129"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.25.6.669"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.36.12.938"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00412.2011"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","unstructured":"HirschJC. MoscaRS. BoveEL.Complete repair of tetralogy of Fallot in the neonate results in the modern era. vol.232. n.d.","DOI":"10.1097\/00000658-200010000-00006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00989-X"},{"issue":"5","key":"e_1_2_10_13_1","first-page":"206","article-title":"Repair of tetralogy of Fallot in infancy. Effect of pulmonary artery size on outcome","volume":"84","author":"Groh MA","year":"1991","journal-title":"Circulation"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.10.060"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.11.040"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.04.102"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.02.040"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.03.019"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.12121"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.03.153"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.06.012"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.6.1923"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","unstructured":"LewisMJ. KennedyKF. GinnsJ. et al.Procedural success and adverse events in pulmonary artery stenting insights from the NCDR. vol.67.2016.","DOI":"10.1016\/j.jacc.2016.01.025"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22356"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.110.961029"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.10.016"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951108002424"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-007-0631-8"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25443"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1017\/S104795111500219X"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25768"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/137985"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27593"},{"key":"e_1_2_10_34_1","unstructured":"RendasA. BranthwaiteM. ReidL.Growth of pulmonary circulation in normal pig\u2010structural analysis and cardiopulmonary function. n.d."},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.02.030"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00868.2012"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000000203"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2007.10.022"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-16"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27800"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.24710"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00029.2005"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00398.2006"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP275860"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29326","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.29326","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T13:30:50Z","timestamp":1693834250000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.29326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,16]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/ccd.29326"],"URL":"https:\/\/doi.org\/10.1002\/ccd.29326","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,16]]},"assertion":[{"value":"2020-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}