{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:11:51Z","timestamp":1789049511822,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter aortic valve replacement (TAVR) can be an effective option for high\u2010risk Aortic Regurgitation (AR) patients. Although international experiences of TAVR for AR are published, U.S. data are limited. This study sought to report the short\u2010term outcomes of TAVR in AR in the U.S. population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Study cohorts were derived from the Nationwide Inpatient Sample (NIS) and Nationwide Readmissions Database (NRD) 2016\u201317. TAVR and AR were identified using ICD\u201010\u2010CM\u2010codes. The key outcomes were all\u2010cause mortality, disabling stroke, valvular complications, complete heart block (CHB)\/permanent pacemaker placement (PPM), open\u2010heart surgery, acute kidney injury (AKI) requiring dialysis, and vascular complications. Multivariate logistic regression was used to adjust for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>915 patients from the NIS (male\u201071%, age \u226565\u201384.2%) and 822 patients from the NRD (male\u201069.3%, age \u226565\u201380.5%) underwent TAVR for AR. The median length of stay (LOS) was 4\u2009days for both cohorts. In\u2010hospital mortality was 2.7%, and 30\u2010day mortality was 3.3%. Disabling strokes were noted in 0.6% peri\u2010procedurally and 1.8% at 30\u2010days. Valve\u2010related complications were 18\u201319% with paravalvular leak (4\u20137%) being the most common. Approximately 11% of patients developed CHB and\/or needed PPM in both cohorts. In NRD, 2.2% of patients required dialysis for AKI, 1.5% developed vascular complications, and 0.6% required open\u2010heart surgery within 30\u2010days post\u2010procedure. Anemia was predictive of increased overall complications and valvular complications, whereas peripheral vascular disease was a predictor of increased valvular complications and CHB\/PPM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TAVR is a promising option in AR. Further studies are necessary for the expansion of TAVR as the standard treatment in AR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29379","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T19:18:00Z","timestamp":1604949480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Transcatheter aortic valve replacement in aortic regurgitation: The U.S. experience"],"prefix":"10.1002","volume":"98","author":[{"given":"Shilpkumar","family":"Arora","sequence":"first","affiliation":[{"name":"Harrington Heart and Vascular Institute, University Hospital Cleveland Medical Center Case Western Reserve University  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9007-289X","authenticated-orcid":false,"given":"Sopan","family":"Lahewala","sequence":"additional","affiliation":[{"name":"Department of Medicine Saint Francis Hospital and Medical Center  Hartford Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Zuzek","sequence":"additional","affiliation":[{"name":"Harrington Heart and Vascular Institute, University Hospital Cleveland Medical Center Case Western Reserve University  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samarthkumar","family":"Thakkar","sequence":"additional","affiliation":[{"name":"Department of Medicine Rochester General Hospital  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinmay","family":"Jani","sequence":"additional","affiliation":[{"name":"Department of Medicine Mount Auburn Hospital\u2010Harvard Medical School  Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Jaswaney","sequence":"additional","affiliation":[{"name":"Harrington Heart and Vascular Institute, University Hospital Cleveland Medical Center Case Western Reserve University  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aanandita","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medicine Sri Guru Ram Das Institute of Medical Sciences &amp; 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