{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T22:24:33Z","timestamp":1748557473921,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about the association of heart failure (HF) chronicity with clinical outcomes after transcatheter mitral valve repair (TMVR) for functional mitral regurgitation (MR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2011 to March 2019, consecutive patients with functional MR who underwent a MitraClip procedure were analyzed. The patients were divided into two groups according to HF duration\u2014those with duration \u226418\u2009months and those with &gt;18\u2009months. The primary outcome measure was a composite of all\u2010cause mortality and re\u2010HF rehospitalization within 1\u2009year after the procedure. These outcomes were also assessed separately. A Cox proportional hazard model was conducted for investigating the association of HF duration with the primary outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 208 patients were analyzed. Patients with HF duration &gt;18\u2009months had a higher rate of the primary outcome compared to those with HF duration \u226418\u2009months (38.1 vs. 19.0%, log\u2010rank <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003). A longer duration of HF was associated with an increased risk of the primary outcomes (adjusted\u2010HR of &gt;18\u2009months, 2.12 95% CI, 1.14\u20134.19; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03; adjusted\u2010HR (hazard ratios) for 1\u2009year increase, 1.05; 95% CI, 1.02\u20131.09; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004). The association of HF duration with the primary outcomes showed a steep rise during the first 2\u2009years of HF duration and progressive increase after 5\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A longer HF duration before TMVR was associated with an increased risk of all\u2010cause mortality or HF rehospitalization. HF duration can be used for the risk stratification marker in patients undergoing TMVR for functional MR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29390","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T21:28:32Z","timestamp":1605821312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of heart failure duration with clinical outcomes after transcatheter mitral valve repair for functional mitral regurgitation"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9446-9963","authenticated-orcid":false,"given":"Atsushi","family":"Sugiura","sequence":"first","affiliation":[{"name":"Heart Center Bonn, Department of Medicine II University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Weber","sequence":"additional","affiliation":[{"name":"Heart Center Bonn, Department of Medicine II University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Tabata","sequence":"additional","affiliation":[{"name":"Heart Center Bonn, Department of Medicine II University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadahiro","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, School of Public Health University of Tokyo  Tokyo Japan"},{"name":"TXP Medical Co. 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan\u2010Malte","family":"Sinning","sequence":"additional","affiliation":[{"name":"Heart Center Bonn, Department of Medicine II University Hospital Bonn  Bonn 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