{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:24:35Z","timestamp":1788405875901,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the efficacy and safety of excimer laser coronary atherectomy (ELCA), as well as, the long\u2010term outcomes and the factors associated with ELCA failure in uncrossable lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Uncrossable lesions constitute a challenge for percutaneous coronary intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter registry included 126 patients with 126 uncrossable lesions. Study endpoints were ELCA success, technical success and a composite of cardiac death, myocardial infarction (MI), and target\u2010lesion revascularization (TLR) on follow\u2010up. Predictors of ELCA failure were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Moderate or severe calcification was present in 79 (62.7%) of the lesions and 58 (46%) were a chronic total occlusion. ELCA success was obtained in 103 (81.8%) patients. Rotational atherectomy was attempted as bailout in 21 out of 23 ELCA failure (91.3%), being successful in 14 (66.7%) of them. Finally, technical and procedural success were achieved in 114 (90.5%) and 110 (87.3%) of the patients. Severe calcification was independently associated with ELCA failure (OR: 3.73, 95% CI: 1.35\u201310.32; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.011). Two (1.6%) patients died (one after a stroke and another patient because of heart failure), 4 (3.2%) developed a non\u2010Q MI without clinical consequences and 1 (0.8%) patient had a Q\u2010MI. Other complications were ventricular tachycardia\/fibrillation (<jats:italic>n<\/jats:italic>\u00a0=\u00a02; 1.6%) and flow\u2010limiting dissection (<jats:italic>n<\/jats:italic>\u00a0=\u00a01, 0.8%). At follow\u2010up (median 424\u2009days), 3 (2.4%) patients died (1 (0.8%) from cardiovascular cause) and 15 (11.9%) required TLR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our multicenter experience, ELCA use demonstrated to be safe and reasonably effective with a rate of events on follow\u2010up relatively low. Severe calcification was associated with ELCA failure.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29392","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T05:39:54Z","timestamp":1606282794000},"page":"1241-1249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Excimer laser coronary atherectomy for uncrossable coronary lesions. A multicenter registry"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7383-6835","authenticated-orcid":false,"given":"Soledad","family":"Ojeda","sequence":"first","affiliation":[{"name":"Division of Interventional Cardiology, Reina Sofia Hospital University of C\u00f3rdoba, Maimonides Institute for Research in Biomedicine of C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9758-0360","authenticated-orcid":false,"given":"Lorenzo","family":"Azzalini","sequence":"additional","affiliation":[{"name":"Division of Cardiology, VCU Health Pauley Heart Center Virginia Commonwealth University  Richmond Virginia USA"},{"name":"The Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Su\u00e1rez de Lezo","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology, Reina Sofia Hospital University of C\u00f3rdoba, Maimonides Institute for Research in Biomedicine of C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurpreet S.","family":"Johal","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology, Reina Sofia Hospital University of C\u00f3rdoba, Maimonides Institute for Research in Biomedicine of C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Barman","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7059-2863","authenticated-orcid":false,"given":"Francisco","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology, Reina Sofia Hospital University of C\u00f3rdoba, Maimonides Institute for Research in Biomedicine of C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neus","family":"Bellera","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Hospital Universitario Vall d'Hebron, Centro de Investigaci\u00f3n Biom\u00e9dica en Red, CIBER CV  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7502-8049","authenticated-orcid":false,"given":"George","family":"Dangas","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6362-7618","authenticated-orcid":false,"given":"Alfonso","family":"Jurado\u2010Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Hospital La Paz, IDIPAZ, CIBER\u2010CV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7189-3307","authenticated-orcid":false,"given":"Annapoorna","family":"Kini","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Romero","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology, Reina Sofia Hospital University of C\u00f3rdoba, Maimonides Institute for Research in Biomedicine of C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7179-1426","authenticated-orcid":false,"given":"Ra\u00fal","family":"Moreno","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Hospital La Paz, IDIPAZ, CIBER\u2010CV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Garcia del Blanco","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Hospital Universitario Vall d'Hebron, Centro de Investigaci\u00f3n Biom\u00e9dica en Red, CIBER CV  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5546-262X","authenticated-orcid":false,"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. 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