{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T12:36:08Z","timestamp":1755693368645,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Percutaneous mitral valve repair with Mitraclip device has been approved for the treatment of symptomatic mitral valve regurgitation in patients deemed high surgical risk. It's unclear whether the presence of preexisting coronary arterial disease (CAD) affects the postprocedural outcomes of Mitraclip.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population was extracted from the 2016 Nationwide Readmissions Data (NRD) using the International Classification of Diseases, Tenth Revision, Clinical Modifications\/Procedure Coding System (ICD\u201010\u2010CM\/PCS) for Mitraclip, preexisting CAD, and postprocedural complications. Study primary endpoints included in\u2010hospital all\u2010cause mortality, cardiogenic shock, acute myocardial infarction (AMI), acute kidney injury (AKI), stroke, acute respiratory failure, length of hospital stay (LOS), and 30\u2010day readmission rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2,539 discharges that had Mitraclip during the index hospitalization, 62.3% had history of preexisting CAD. Mean age was 78.5\u2009years and 46.6% were female. Overall, the presence of preexisting CAD was associated with higher AMI (1.6 vs. 0.4%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01), however, there was no significant differences in terms of in\u2010hospital all\u2010cause mortality (2.2 vs. 2.6%, <jats:italic>p<\/jats:italic> = .52), cardiogenic shock (3.4 vs. 4.1%, <jats:italic>p<\/jats:italic> = .39), AKI (14.7 vs. 13.6%, <jats:italic>p<\/jats:italic> = .43), stroke (0.9 vs. 0.5%, <jats:italic>p<\/jats:italic> = .31), acute respiratory failure (9.7 vs. 8.8%, <jats:italic>p<\/jats:italic> = .43), LOS (5.3 vs. 5.3\u2009days, <jats:italic>p<\/jats:italic> = .85) or 30\u2010day readmission rate (14.6 vs. 14.4%, <jats:italic>p<\/jats:italic> = .92). These results persisted after adjustment for baseline characteristics. The subgroup of CAD patients who received percutaneous coronary intervention (PCI) was associated with higher in\u2010hospital mortality (22.5 vs. 2.0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01), cardiogenic shock (25.0 vs. 3.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01), AMI (22.5 vs. 0.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01), AKI (55.0 vs. 13.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01), stroke (10.0 vs. 0.6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01), acute respiratory failure (45.0 vs. 8.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01), and longer LOS (21.5 vs. 5.1\u2009days, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01), however there was no significant difference in 30\u2010day readmission rate (15.0 vs. 14.5%, <jats:italic>p<\/jats:italic> = .95).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preexisting CAD was associated with higher in\u2010hospital AMI post\u2010Mitraclip but with comparable mortality and other morbidities. Patients who received PCI during the same index hospitalization had higher in\u2010hospital mortality and morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29404","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T15:23:46Z","timestamp":1606577026000},"page":"919-924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of preexisting coronary arterial disease in patients undergoing percutaneous mitral valve repair (MitraClip)"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7361-5725","authenticated-orcid":false,"given":"Kristina","family":"Gifft","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Missouri Hospital  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1092-0807","authenticated-orcid":false,"given":"Jad","family":"Omran","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of California San Diego  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadi","family":"Ghrair","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Missouri Hospital  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haytham","family":"Allaham","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Maryland  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Eniezat","sequence":"additional","affiliation":[{"name":"School of Medicine Jordan University of Science and Technology  Irbid Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Obai","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kaiser Permanente  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6812-8161","authenticated-orcid":false,"given":"Tariq","family":"Enezate","sequence":"additional","affiliation":[{"name":"Department of Cardiology Harbor Medical Center\u2010University of California Log Angeles  Torrance California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.01.047"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.08.723"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806640"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-014-0153-1"},{"key":"e_1_2_8_6_1","unstructured":"Agency for Healthcare Research and Quality2014 Introduction to the NRD. 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