{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T20:34:39Z","timestamp":1778099679805,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this systematic review and meta\u2010analysis was to provide a comprehensive estimate for spontaneous coronary artery dissection (SCAD) related mortality, and explore factors associated with an increased risk of death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>SCAD is an infrequent but increasingly recognized cause of acute coronary syndrome. Despite a growing body of evidence, there have been few detailed examinations of SCAD associated mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched MEDLINE, EMBASE, Cochrane, Web of Science and Google Scholar databases through May 7, 2020. We included studies reporting mortality data, confirmed SCAD with coronary angiography and included \u226510 participants. We excluded non\u2010English studies, conference abstracts, review articles and duplicate datasets. Random\u2010effects meta\u2010analysis and meta\u2010regression were used to evaluate estimates and predictors of mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From an initial 1,131 articles, 34 studies with 2,817 patients were eligible for inclusion. The weighted mean age was 50\u2009years, and 84% of participants were female. The pooled estimate for SCAD mortality was 1% (Proportion 0.01; 95% CI, 0.00\u20130.02). The mean duration of follow\u2010up was 33\u2009months. Meta\u2010regression showed male sex was associated with 3.5\u2010fold increased odds of mortality (OR, 3.50; 95% CI, 1.22\u201310.03). In addition, smoking (current or previous) was associated with a 15\u2010fold increased risk of mortality (OR 15.32; 95% CI, 2.88\u201381.41).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis has shown that SCAD is associated with favorable survival outcomes with an estimated mortality of 1% over a mean follow\u2010up period of 33\u2009months. We also found male sex and smoking were associated with an increased risk of mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29488","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T18:03:06Z","timestamp":1611597786000},"page":"1211-1220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Mortality in spontaneous coronary artery dissection: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2595-1841","authenticated-orcid":false,"given":"Cobi","family":"Adams","sequence":"first","affiliation":[{"name":"Department of Medicine Bond University  Robina Queensland Australia"},{"name":"Department of Cardiology Gold Coast University Hospital  Gold Coast Queensland 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