{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:34:10Z","timestamp":1782743650867,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000659","name":"Research Trainees Coordinating Centre","doi-asserted-by":"publisher","award":["CL\u20102016\u201027\u2010001"],"award-info":[{"award-number":["CL\u20102016\u201027\u2010001"]}],"id":[{"id":"10.13039\/501100000659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine whether a permanent pacemaker (PPM) in situ can enhance survival after transcatheter aortic valve implantation (TAVI), in a predominantly inoperable or high risk cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>New conduction disturbances are the most frequent complication of TAVI, often necessitating PPM implantation before hospital discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed an observational cohort analysis of the UK TAVI registry (2007\u20132015). Primary and secondary endpoints were 30\u2010day post\u2010discharge all\u2010cause mortality and long\u2010term survival, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 8,651 procedures, 6,815 complete datasets were analyzed. A PPM at hospital discharge, irrespective of when implantation occurred (PPM 1.68% [22\/1309] vs. no PPM 1.47% [81\/5506], odds ratio [OR] 1.14, 95% confidence interval [CI] 0.71\u20131.84; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.58), or a PPM implanted peri\u2010 or post\u2010TAVI only (PPM 1.44% [11\/763] vs. no PPM 1.47% [81\/5506], OR 0.98 [0.51\u20131.85]; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.95) did not significantly reduce the primary endpoint. Patients with a PPM at discharge were older, male, had right bundle branch block at baseline, were more likely to have received a first\u2010generation self\u2010expandable prosthesis and had experienced more peri\u2010 and post\u2010procedural complications including bailout valve\u2010in\u2010valve rescue, bleeding and acute kidney injury. A Cox proportional hazards model demonstrated significantly reduced long\u2010term survival in all those with a PPM, irrespective of implantation timing (hazard ratio [HR] 1.14 [1.02\u20131.26]; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.019) and those receiving a PPM only at the time of TAVI (HR 1.15 [1.02\u20131.31]; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.032). The reasons underlying this observation warrant further investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A PPM did not confer a survival advantage in the first 30\u2009days after hospital discharge following TAVI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29498","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T14:26:52Z","timestamp":1611757612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Survival relative to pacemaker status after transcatheter aortic valve implantation"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4494-8269","authenticated-orcid":false,"given":"Aung","family":"Myat","sequence":"first","affiliation":[{"name":"Sussex Cardiac Center Brighton and Sussex University Hospitals NHS Trust  Brighton UK"},{"name":"Division of Clinical and Experimental Medicine Brighton and Sussex Medical School  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Mouy","sequence":"additional","affiliation":[{"name":"Division of Clinical and Experimental Medicine Brighton and Sussex Medical School  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Buckner","sequence":"additional","affiliation":[{"name":"Division of Clinical and Experimental Medicine Brighton and Sussex Medical School  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Cockburn","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Center Brighton and Sussex University Hospitals NHS Trust  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Baumbach","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute Queen Mary University of London  London UK"},{"name":"Barts Heart Center Barts Health NHS Trust  London UK"},{"name":"Section of Cardiology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"MacCarthy","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian P.","family":"Banning","sequence":"additional","affiliation":[{"name":"Oxford Heart Center Oxford University Hospitals NHS Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Curzen","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Southampton NHS Foundation Trust  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6357-4595","authenticated-orcid":false,"given":"Roland","family":"Hilling\u2010Smith","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Center Brighton and Sussex University Hospitals NHS Trust  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9039-6130","authenticated-orcid":false,"given":"Daniel J.","family":"Blackman","sequence":"additional","affiliation":[{"name":"Yorkshire Heart Centre The Leeds Teaching Hospitals NHS Trust  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mullen","sequence":"additional","affiliation":[{"name":"Barts Heart Center Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"de Belder","sequence":"additional","affiliation":[{"name":"Barts Heart Center Barts Health NHS Trust  London UK"},{"name":"Department of Cardiology The James Cook University Hospital  Middlesbrough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospitals Plymouth NHS Trust  Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kovac","sequence":"additional","affiliation":[{"name":"Glenfield Hospital University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh","family":"Manoharan","sequence":"additional","affiliation":[{"name":"Royal Victoria Hospital Belfast Health and Social Care Trust  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azfar","family":"Zaman","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine, Newcastle University  Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Muir","sequence":"additional","affiliation":[{"name":"Department of Cardiology The James Cook University Hospital  Middlesbrough 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