{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T22:57:17Z","timestamp":1784156237008,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,31]],"date-time":"2021-01-31T00:00:00Z","timestamp":1612051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sex\u2010based differences in transcatheter aortic valve replacement (TAVR) outcomes have been previously documented. However, whether these differences persist with contemporary third generation transcatheter heart valves (THVs) is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We utilized Vizient's clinical database\/resource manager (CDB\/RM\u2122) to identify patients who underwent TAVR between January 1, 2018 and March 31, 2020 to compare in\u2010hospital outcomes between males and females. The primary endpoint was in\u2010hospital mortality. Secondary endpoints included key in\u2010hospital complications, length of stay, discharge disposition, and cost. Unadjusted, propensity\u2010score matched and risk\u2010adjusted analyses of outcomes were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 44,280 patients (24,842 males, 19,438 females) underwent TAVR. The primary endpoint of in\u2010hospital mortality was higher in females than in males (1.6 vs. 1.1% <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001) in unadjusted analysis and persisted following propensity matching (1.6 vs. 0.9%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001) and multivariable logistic regression with various risk\u2010adjustment models. In the most comprehensive model adjusting for age, race, and clinical comorbidities, female sex was associated with 34% greater odds of in\u2010hospital death (95% CI 20\u201350%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001). Unadjusted and risk\u2010adjusted rates of post\u2010TAVR stroke, vascular complication, and blood transfusion were higher in females. Moreover, females demonstrated longer hospitalizations, higher costs and reduced rates of independent discharge home.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sex\u2010based differences in TAVR in\u2010hospital outcomes persist in contemporary practice with third generation transcatheter heart valves. Further research is needed to assess the reasons for these observed disparities and to identify effective mitigation strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29499","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T07:51:25Z","timestamp":1612165885000},"page":"176-183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["<scp>Sex\u2010specific in\u2010hospital<\/scp> outcomes of transcatheter aortic valve replacement with third generation transcatheter heart valves"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9465-8150","authenticated-orcid":false,"given":"Trevor","family":"Simard","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic School of Medicine  Rochester Minnesota 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