{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:28:15Z","timestamp":1761845295862,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Reduced levels of hemoglobin (Hb) represent an established marker of impaired outcomes and increased cardiovascular risk in patients with coronary artery disease, challenging the management of dual antiplatelet therapy (DAPT). However, while anemia has emerged as an independent predictor of suboptimal platelet inhibition in patients receiving clopidogrel, no study has so far evaluated the impact of Hb levels on high\u2010on treatment platelet reactivity (HRPR) with ticagrelor and their prognostic consequences, that were the aim of the present study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients on DAPT with ASA\u2009+\u2009Ticagrelor (90\u2009mg\/twice a day) after percutaneous coronary revascularization for ACS were scheduled for platelet function assessment 30\u201390\u2009days post\u2010discharge. Aggregation tests were performed by multiple electrode aggregometry. Suboptimal platelet inhibition (HRPR\u2010high residual platelet reactivity was defined if above the lower limit of normality (417\u2009AU*min). The primary study endpoint was defined as the occurrence of major cardiovascular events (a composite of cardiovascular death, recurrent acute coronary syndrome [MI], target vessel revascularization) at longest available follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 397 patients that were divided according to tertiles values of Hb (&lt;\u200912.7, 12\u20137\u201314.09, \u226514.1\u00a0g\/dl). Patients with lower Hb were older and displayed a more severe cardiovascular risk profile. Mean levels of platelet reactivity were enhanced in patients with lower Hb after stimulation with TRAP peptide (TRAP test, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03) and ADP (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.02). Elevated platelet reactivity (HRPR) on Ticagrelor was more frequent among patients with reduced Hb (16.4% vs. 12% vs. 5.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005, adjusted OR [95%CI]\u00a0=\u00a01.71[0.996;3.01], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.056). At a mean follow\u2010up of 820.9\u2009\u00b1\u2009553.4\u2009days, 21.4% of the patients experienced the primary composite endpoint, with a higher rate of events in patients with lower Hb (27.6% vs. 22.6% vs. 13.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.006, adjusted HR [95%CI]\u00a0=\u00a01.51[1.12; 2.03], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.006), mainly driven by a higher rate of recurrent ACS. After correction for baseline differences lower Hb tertiles but not HRPR emerged as independent predictor of MACE (adjusted HR [95%CI]\u00a0=\u00a00.98[0.50; 1.92], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.95).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the present study, we demonstrated that among patients on DAPT with ASA and ticagrelor after PCI for ACS, lower Hb levels are independently associated with a higher rate of HRPR and an increased rate of major ischemic events, and especially for recurrent ACS, although with no impact on survival. Neutral prognostic effect of HRPR was observed across Hb tertiles.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29512","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T19:20:49Z","timestamp":1612380049000},"page":"1309-1316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Low hemoglobin predicts high\u2010platelet reactivity and major cardiovascular ischemic events at long\u2010term follow\u2010up among <scp>ACS<\/scp> patients receiving dual antiplatelet therapy with ticagrelor"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6506-8397","authenticated-orcid":false,"given":"Monica","family":"Verdoia","sequence":"first","affiliation":[{"name":"Division of Cardiology Ospedale degli Infermi  Biella Italy"},{"name":"Department of Translational Medicine Eastern Piedmont University  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Rolla","sequence":"additional","affiliation":[{"name":"Clinical Chemistry, Azienda Ospedaliera\u2010Universitaria \u201cMaggiore della Carit\u00e0\u201d Eastern Piedmont University  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Pergolini","sequence":"additional","affiliation":[{"name":"Clinical Chemistry, Azienda Ospedaliera\u2010Universitaria \u201cMaggiore della Carit\u00e0\u201d Eastern Piedmont University  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco","family":"Gioscia","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera\u2010Universitaria \u201cMaggiore della Carit\u00e0\u201d Eastern Piedmont University  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Nardin","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Eastern Piedmont University  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Negro","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Eastern Piedmont University  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Viglione","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Eastern Piedmont University  Novara Italy"},{"name":"Azienda Ospedaliera\u2010Universitaria \u201cMaggiore della Carit\u00e0\u201d Eastern Piedmont University  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Suryapranata","sequence":"additional","affiliation":[{"name":"Department of Cardiology UMC St Radboud  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvin","family":"Kedhi","sequence":"additional","affiliation":[{"name":"Department of Cardiology ISALA Hospital  Zwolle The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"De Luca","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Eastern Piedmont University  Novara Italy"},{"name":"Azienda Ospedaliera\u2010Universitaria \u201cMaggiore della Carit\u00e0\u201d Eastern Piedmont University  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Novara Atherosclerosis Study Group (NAS)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa575"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010956"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2020.03.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx419"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908419"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvz020"},{"issue":"5","key":"e_1_2_9_8_1","first-page":"491","article-title":"Baseline anemia in patients undergoing percutaneous coronary intervention after an acute coronary syndrome\u2010a paradox of high bleeding risk, high ischemic risk, and complex coronary disease","volume":"30","author":"Yazji K","year":"2017","journal-title":"J IntervCardiol"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.101"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000134964.01697.C7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.070"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-018-1049-x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-013-0028-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.034"},{"key":"e_1_2_9_15_1","first-page":"719","article-title":"The influence of clinicalcharacteristics, laboratory and inflammatory markers on \u201chigh ontreatmentplatelet reactivity\u201d as measured with different platelet function tests","volume":"102","author":"Elsenberg EH","year":"2009","journal-title":"ThrombHaemost"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.01.001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.05.024"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.04.021"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2012.01428.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.04.047"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.09.023"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(02)00134-5"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.02.052"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.076"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.03.034"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.02.064"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186961"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1676529"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.06.011"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13177"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2015.04.014"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114053"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12376"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.06.029"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.12.004"},{"issue":"2","key":"e_1_2_9_36_1","first-page":"124","article-title":"Prevalence rate of laboratory defined aspirin resistance in cardiovascular disease patients: a systematic review and meta\u2010analysis","volume":"11","author":"Ebrahimi P","year":"2020","journal-title":"Caspian J Intern Med"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.11.049"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.3355"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904327"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11506-9"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199810)59:2<105::AID-AJH1>3.0.CO;2-1"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1279-2"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29512","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.29512","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:56:42Z","timestamp":1693198602000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.29512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/ccd.29512"],"URL":"https:\/\/doi.org\/10.1002\/ccd.29512","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"2020-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}