{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:23:28Z","timestamp":1781670208587,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The transradial approach (TRA) for catheter interventions decreases vascular complications and bleeding versus transfemoral approach. Reducing time to hemostasis and preventing radial artery occlusion (RAO) following TRA are important and incompletely realized aspirations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This first\u2010in\u2010human study sought to evaluate the efficacy of a novel, topically applied compound (hydrophobically modified polysaccharide\u2010chitosan, hm\u2010P) plus minimal required pneumatic compression, to achieve rapid radial arterial hemostasis in post\u2010TRA procedures compared with de facto standards.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>About 50 adult patients undergoing 6 French diagnostic TRA procedures were prospectively enrolled. At procedure completion, a topical hm\u2010P impregnated patch was placed over the dermotomy and TR Band (TRB) compression was applied to the access site. This patch was used as part of a novel rapid deflation protocol with a primary outcome of time to hemostasis. Photographic and vascular ultrasound evaluation of the radial artery was performed to evaluate the procedural site.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Time to hemostasis was 40.5 min (IQR: 38\u201350\u2009min) with the majority of patients (<jats:italic>n<\/jats:italic> = 39, 78%) not requiring reinflation. Patients with bleeding requiring TRB reinflation were more likely to have low body weight and liver dysfunction, with absence of hypertension and LV dysfunction. The rate of RAO was 0% with predischarge radial artery patency documented in all patients using vascular ultrasound. One superficial hematoma was noted. No late bleeding events or cutaneous reactions were reported in the study follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Topical application of hm\u2010P in conjunction with pneumatic compression was safe and resulted in rapid and predictable hemostasis at the arterial puncture site.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29529","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T13:47:32Z","timestamp":1613310452000},"page":"786-794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Safe and rapid radial hemostasis achieved using a novel topical hemostatic patch: Results of a first\u2010in\u2010human pilot study using hydrophobically modified polysaccharide\u2010chitosan"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1923-1522","authenticated-orcid":false,"given":"Rajeev","family":"Anchan","sequence":"first","affiliation":[{"name":"Section of Cardiology, Department of Medicine University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1736-8015","authenticated-orcid":false,"given":"Joseph","family":"Venturini","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Larsen","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Lee","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Besser","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Kalathiya","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Paul","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5123-7129","authenticated-orcid":false,"given":"John","family":"Blair","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1834-3971","authenticated-orcid":false,"given":"Sandeep","family":"Nathan","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60292-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.01.039"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs169"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60404-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.08.023"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.04.014"},{"issue":"6","key":"e_1_2_9_8_1","article-title":"Transradial vs. Transfemoral approach in cardiac catheterization: a literature review","volume":"9","author":"Anjum I","year":"2017","journal-title":"Cureus"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1372243"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.112.965269"},{"key":"e_1_2_9_11_1","first-page":"49","article-title":"Radial artery use and reuse","author":"Gupta S","year":"2015","journal-title":"Cardiac Interv Today"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.10.016"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25232"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25661"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22610"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/abr.abr_164_16"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.07.020"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21639"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27775"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27526"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318248baa1"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2016.04.052"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.638627"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.03.007"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22963"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.12.033"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-16-00816"},{"issue":"4","key":"e_1_2_9_28_1","first-page":"103","article-title":"Use of StatSeal advanced disc to decrease time to hemostasis in transradial cardiac procedures\/a quality improvement project","volume":"6","author":"Condry H","year":"2016","journal-title":"Int J Nurs Sci"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00101"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2018.03.026"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-019-01520-z"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCN.0000000000000115"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181099"},{"issue":"10","key":"e_1_2_9_34_1","first-page":"328","article-title":"Comparison of hemostasis times with a kaolin\u2010based hemostatic pad (QuikClot radial) vs mechanical compression (TR band) following transradial access: a pilot prospective study","volume":"29","author":"Roberts JS","year":"2017","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2018.11.026"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2019.04.014"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005029"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29529","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.29529","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T22:21:12Z","timestamp":1692570072000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.29529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,12]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/ccd.29529"],"URL":"https:\/\/doi.org\/10.1002\/ccd.29529","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,12]]},"assertion":[{"value":"2020-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}