{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:41:24Z","timestamp":1788795684885,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess outcomes in patients with acute mitral regurgitation (MR) following acute myocardial infarction (AMI) who received percutaneous mitral valve repair (PMVR) with the MitraClip device and to compare outcomes of patients who developed cardiogenic shock (CS) to those who did not (non\u2010CS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute MR after AMI may lead to CS and is associated with high mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This registry analyzed patients with MR after AMI who were treated with MitraClip at 18 centers within eight countries between January 2016 and February 2020. Patients were stratified into CS and non\u2010CS groups. Primary outcomes were mortality and rehospitalization due to heart failure. Secondary outcomes were acute procedural success, functional improvement, and MR reduction. Multivariable Cox regression analysis evaluated association of CS with clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 93 patients analyzed (age 70.3\u2009\u00b1\u200910.2\u2009years), 50 patients (53.8%) experienced CS before PMVR. Mortality at 30\u2009days (10% CS vs. 2.3% non\u2010CS; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.212) did not differ between groups. After median follow\u2010up of 7\u00a0months (IQR 2.5\u201317\u2009months), the combined event mortality\/re\u2010hospitalization was similar (28% CS vs. 25.6% non\u2010CS; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.793). Likewise, immediate procedural success (90% CS vs. 93% non\u2010CS; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.793) and need for reintervention (CS 6% vs. non\u2010CS 2.3%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.621) or re\u2010admission due to HF (CS 13% vs. NCS 23%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.253) at 3\u00a0months did not differ. CS was not independently associated with the combined end\u2010point (hazard ratio 1.1; 95% CI, 0.3\u20134.6; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.889).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients found to have significant MR during their index hospitalization for AMI had similar clinical outcomes with PMVR whether they presented in or out of cardiogenic shock, provided initial hemodynamic stabilization was first achieved before PMVR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29552","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T20:19:02Z","timestamp":1613852342000},"page":"1259-1267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Use of MitraClip for mitral valve repair in patients with acute mitral regurgitation following acute myocardial infarction: Effect of cardiogenic shock on outcomes (IREMMI Registry)"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5841-5514","authenticated-orcid":false,"given":"Rodrigo","family":"Est\u00e9vez\u2010Loureiro","sequence":"first","affiliation":[{"name":"Interventional Cardiology Unit Hospital \u00c1lvaro Cunqueiro  Vigo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mony","family":"Shuvy","sequence":"additional","affiliation":[{"name":"Heart Institute Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7295-1153","authenticated-orcid":false,"given":"Maurizio","family":"Taramasso","sequence":"additional","affiliation":[{"name":"Heart Valve Clinic University Hospital of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Benito\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit Complejo Asistencial Universitario de Leon  Leon Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Denti","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery San Raffaele University Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dabit","family":"Arzamendi","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit Hospital Sant Pau i Santa Creu  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-1815","authenticated-orcid":false,"given":"Marianna","family":"Adamo","sequence":"additional","affiliation":[{"name":"Cardiac Catheterization Laboratory, Cardiothoracic Department Spedali Civili Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-9060","authenticated-orcid":false,"given":"Xavier","family":"Freixa","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit Hospital Clinic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Villablanca","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, Structural Heart Disease Interventions, Endovascular Interventions The Center for Structural Heart Disease, Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Krivoshei","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kantonsspital Baden  Baden Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1269-6733","authenticated-orcid":false,"given":"Neil","family":"Fam","sequence":"additional","affiliation":[{"name":"Division of Cardiology St. Michael's Hospital, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Spargias","sequence":"additional","affiliation":[{"name":"Department of Transcatheter Heart Valves HYGEIA Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3000-9722","authenticated-orcid":false,"given":"Andrew","family":"Czarnecki","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Sunnybrook Heath Sciences Centre University of Toronto, Shulich Heart Centre  Tronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Haberman","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center Affiliated to the Hebrew University  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoram","family":"Agmon","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rambam Medical Center, and B. 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